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Efficacy of probiotic supplementation in reducing primary dysmenorrhea: a double-blinded randomized controlled trial.

Primary dysmenorrhea is painful menstruation in the absence of pelvic pathology, whereas secondary dysmenorrhea is menstrual pain attributable to an underlying pelvic disease (e.g., endometriosis). Nonsteroidal anti-inflammatory drugs (NSAIDs) are …

Published: March 17, 2026, midnight
Intra-Patient Variability in the Number of Retrieved Oocytes and Ovarian Response Categories Between Consecutive IVF Cycles.

To examine intra-patient variability in retrieved oocyte numbers across consecutive in-vitro fertilization (IVF) ovarian stimulation (OS) cycles with an identical OS protocol.

Published: March 17, 2026, midnight
Lactoferrin as a Non-Hormonal Therapeutic Candidate for Endometriosis: Mechanisms and Future Directions.

The pathogenesis and progression of endometriosis may involve a complex combination of multiple factors, including chronic inflammation and oxidative stress. Hormonal therapy, the current standard for pharmacotherapy in endometriosis, causes …

Published: March 5, 2026, midnight
EXPRESSION OF CONCERN: Melatonin Protects Against Endometriosis via Regulation of Matrix Metalloproteinase-3 and an Apoptotic Pathway.

S. Paul, P. Bhattacharya, P. D. Mahapatra, and S. Swarnakar, "Melatonin Protects Against Endometriosis via Regulation of Matrix Metalloproteinase-3 and an Apoptotic Pathway," Journal of Pineal Research 49, no. 2 …

Published: March 3, 2026, midnight
The role of gut microbiota in modulating estrogen in the inflammatory milieu of endometriosis: A molecular and pathophysiological perspective.

Endometriosis is a prevalent estrogen-dependent chronic inflammatory condition that affects millions of women of reproductive age worldwide. It is characterized by the growth of endometrial tissue outside the uterine cavity, …

Published: Feb. 24, 2026, midnight
TMEM119 Links to Ovarian Endometriosis Progression via MAPK-Mediated Suppression of Ectopic Endometrial Stromal Cell Senescence.

Transmembrane protein TMEM119 has been implicated in tumor progression (e.g., ovarian cancer), but its role and underlying mechanism in ovarian endometriosis (EM) remain elusive. Thus, this study aimed to investigate …

Published: Feb. 19, 2026, midnight
The letrozole use in reproductive medicine: Beyond aromatase inhibition - a comprehensive review.

Letrozole and other aromatase inhibitors are increasingly recognized as first-line ovulation induction (OI) medications, offering an efficient and physiologic approach to ovarian stimulation that enhances outcomes in reproductive medicine. By …

Published: Feb. 17, 2026, midnight
Looking at endometriosis-diagnosis and disease mechanisms through a mechanical lens.

Endometriosis is a chronic gynecological disorder marked by the growth of endometrial-like tissue outside the uterus, often resulting in pain and infertility and affecting overall quality of life. Despite its …

Published: Feb. 5, 2026, midnight
Anything but Endo: Diagnostic Buck-Passing in Endometriosis Diagnosis.

People living with endometriosis, a disease in which tissue similar to the lining of the uterus grows elsewhere in the body, often experience prolonged diagnostic journeys because of symptom variability, …

Published: Jan. 20, 2026, midnight
Characteristics and Preoperative Management of Adolescent Patients With Pathology-Confirmed Endometriosis: A Multi-Institutional Study.

Endometriosis affects an estimated 25% to 75% of adolescent patients with chronic pelvic pain; the diagnosis is made surgically and treatment typically consists of hormone suppression and pain management strategies. …

Published: Jan. 19, 2026, midnight
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