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TREM2 Deficiency Attenuates Endometriosis Progression by Inhibiting M2 Polarization of SpMs and Suppressing SIRPα to Enhance Phagocytosis.

Endometriosis (EMS) is characterised by a disrupted peritoneal immune microenvironment where M2 macrophage polarization and impaired phagocytosis promote lesion survival. Single-cell RNA-seq (ScRNAseq) of the peritoneal macrophages from EMS patient …

Published: Aug. 5, 2026, midnight
Shared Genetic Architecture and Pleiotropic Loci Linking Endometriosis and Inflammatory Bowel Disease: An Integrative GWAS, Colocalization, and Mendelian Randomization Study.

Endometriosis (EMS) and inflammatory bowel disease (IBD) are both chronic inflammatory disorders with overlapping clinical features, suggesting a potentially shared etiology. Although epidemiological studies have reported an association between the …

Published: July 29, 2026, midnight
FOSL2-driven SASP in endometrial stroma promotes the inflammation of endometriosis.

Endometriosis (EMs) is characterized by chronic pelvic inflammation, but the etiology of this inflammation remains poorly understood. The senescence-associated secretory phenotype (SASP), whereby senescent cells secrete pro-inflammatory cytokines, is a …

Published: July 24, 2026, midnight
p53-mediated epigenetic regulation in the pathogenesis of endometriosis.

Endometriosis (EMs) is a common gynecological disorder affecting reproductive‑aged women, characterized by ectopic endometrial growth and chronic pelvic pain that severely impairs quality of life. Although its pathogenesis remains incompletely …

Published: July 21, 2026, midnight
Associations between granulysin and ovarian endometriosis: A 2-sample Mendelian randomization study.

Endometriosis (EMS) is a chronic inflammatory disease defined by the presence of endometrial-like tissue outside the uterine cavity. Ovarian EMS is considered the most prevalent disease phenotype. However, the causal …

Published: July 19, 2026, midnight
Comprehensive transcript and protein profiling reveals ERα rather than ERβ as the predominant estrogen receptor in human endometriotic lesions.

Endometriosis (EMS) is a chronic estrogen-dependent inflammatory disease. Although several studies have suggested a key role for estrogen receptor ERβ in EMS lesion development, its detection has been challenged by …

Published: July 11, 2026, midnight
Metabolic remodeling of endometriosis microenvironment: Energy stress and immune evasion.

Endometriosis (EMs) is an estrogen-dependent chronic inflammatory gynecological disease characterized by ectopic growth of endometrial tissues, leading to dysmenorrhea, pelvic pain, and infertility. Although the retrograde menstruation theory clarifies the …

Published: July 9, 2026, midnight
FOXQ1 promotes endometriosis development by enhancing mitochondrial function.

Endometriosis (EMs) is a pathological condition characterized by the ectopic growth of endometrial tissue outside the uterine cavity. This study aimed to investigate the role of FOXQ1 in the pathogenesis …

Published: July 7, 2026, midnight
Associations Among Parental Rearing Patterns, Psychological Resilience and Coping Styles in Adolescent Females with Endometriosis.

Adolescent endometriosis (EMs) imposes substantial physical and psychological burdens on young female patients, and adaptive coping strategies are vital for their health management. This study aimed to explore the latent …

Published: July 3, 2026, midnight
[Analysis and projection of the disease burden of endometriosis and polycystic ovary syndrome-related infertility among women aged 15-49 years in China and globally from 1990 to 2021].

Objective: To investigate the burden of endometriosis (EMs)-related and polycystic ovary syndrome (PCOS)-related infertility among women aged 15-49 years in China and globally, and to project trends over the next …

Published: July 1, 2026, midnight
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