Endocrine roles of vitamin D in female reproduction: Mechanisms and clinical implications.
Vitamin D a fat-soluble steroid hormone signals through Vitamin D Receptors (VDRs) located throughout the ovaries, uterus, placenta, hypothalamus, and pituitary gland, influencing immune regulation and female reproductive physiology. This …
Endo-SOFT: study protocol for a national multicentre randomised controlled trial - first-line surgery versus first-line assisted reproductive technologies in patients with advanced endometriosis.
Endometriosis is a chronic, inflammatory and oestrogen-dependent disease frequently causing infertility. Assisted reproductive technologies (ART) are often required to achieve pregnancy, especially in women with advanced endometriosis. To date, there …
Intra-Patient Variability in the Number of Retrieved Oocytes and Ovarian Response Categories Between Consecutive IVF Cycles.
To examine intra-patient variability in retrieved oocyte numbers across consecutive in-vitro fertilization (IVF) ovarian stimulation (OS) cycles with an identical OS protocol.
Decoding the Endometriosis-Associated Infertility Microenvironment: A Review of FTIR and Raman Spectroscopic Insights into Follicular Fluid.
Background: Endometriosis is a major cause of female infertility. It significantly impacts oocyte quality and embryonic development. The condition's pathophysiological mechanisms are multifactorial. However, they are believed to be reflected …
Advanced Management of Severe Adenomyosis in IVF: A Personalized Approach With Extended GnRH Agonist and Letrozole Therapy.
The objective of this study is to evaluate the effectiveness of prolonged GnRH agonist (GnRH-a) suppression combined with letrozole and intensive luteal phase support in a patient with severe adenomyosis …
Effects of E2/ERβ on follicular granulosa cells and on AMH/Smad signalling in endometriosis.
Patients with endometriosis have greater risk of infertility, which is associated with compromised ovarian function. Dysfunction in follicular granulosa cells and hyperactivation of oestrogen receptor beta (ERβ) are evident in …
Correction: Impact of endometriotic cystectomy on ovarian reserve function and ovulation induction outcomes in women with endometriosis undergoing assisted reproductive technology.
[This corrects the article DOI: 10.3389/fendo.2025.1687765.].
The letrozole use in reproductive medicine: Beyond aromatase inhibition - a comprehensive review.
Letrozole and other aromatase inhibitors are increasingly recognized as first-line ovulation induction (OI) medications, offering an efficient and physiologic approach to ovarian stimulation that enhances outcomes in reproductive medicine. By …