The LYSET gene encodes the LYSET transmembrane protein, which regulates lysosome biogenesis by activating the mannose-6-phosphate (M6P) pathway. This is an autosomal recessive, ultrarare, and severe progressive skeletal dysplasia with …
Endometriosis and major depressive disorder (MDD) pose significant global health burdens. Despite pathophysiological overlaps, existing epidemiological studies predominantly examine their unidirectional associations, often constrained by cross-sectional designs and small sample …
Both genetic and environmental factors affect human stature, including overall height and familial short stature (FSS), and it is associated with various health outcomes. However, the study of genetic connections …
Bilateral salpingo-oophorectomy (BSO) and hormone replacement therapy (HRT) exert opposing effects on systemic sex hormone exposure. Although HRT is frequently prescribed following BSO to mitigate surgical menopause, their combined impact …
Sex cord-like morphology is now a well-known feature of occasional examples of endometrioid carcinoma of the ovary or fallopian tube. Recently, we have observed that these tumors are frequently negative …
This study evaluates the association between obesity and the presence of bowel endometriosis in patients undergoing surgery.
This study aims to investigate the effect of endometriosis (EMs) on fertility and to assess the causal relationship between EMs and fertility using two-sample Mendelian randomization (MR). We conducted an …
Dyslipidaemia is related to endometriosis, but it is not known which lipid component is most relevant, and whether the observed correlation reflects the causal relationship. The relationship between triglycerides (TG) …
To assess the correlation between patients' knowledge of endometriosis and their quality of life.
Endometriosis can impair natural reproduction through multiple mechanisms, including distortion of pelvic anatomy and chronic peritoneal inflammation. On this basis, surgical treatment might be reasonably expected to benefit. However, clinical …