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H2S-Releasing Aspirin Nanoparticles Alleviate Endometriosis and Associated Anxiety.

Despite ongoing challenges in developing effective non-surgical and non-hormonal treatments for endometriosis, the psychological manifestations of the disease-particularly anxiety-remain comparatively underexplored. In this study, a hydrogen sulfide (H2S)-releasing aspirin derivative, …

Published: Feb. 8, 2026, midnight
Clinical and cost-effectiveness of medical management versus surgery for deep infiltrating endometriosis: synopsis from the DIAMOND RCT.

Deep endometriosis causes significant pain which adversely affects quality of life and utilises healthcare and wider societal resources. Laparoscopic excision of endometriosis has shown to improve pain symptoms in observational …

Published: Jan. 28, 2026, midnight
Endometriosis in adolescents: A state-of-the-art review.

Endometriosis, once considered rare in adolescents, is now recognized as a common cause of chronic pelvic pain and dysmenorrhea in individuals aged 10-21. This state-of-the-art review explores the evolution of …

Published: Jan. 22, 2026, midnight
Hormonal treatment in endometriosis fails to prevent IL-6 increase and endometrium fibrosis but regulates levels of CYP17A, VEGF, and NFkB.

Endometriosis is a gynecological inflammatory disease characterized by the presence of ectopic endometrial-like tissue. This study aims to elucidate the effect of hormonal treatment in human endometriosis inflammation, angiogenesis and …

Published: Jan. 20, 2026, midnight
Caesarean scar endometriosis involving the uterine wall.

Endometriosis in a surgical scar is a rare but important clinical phenomenon that can lead to significant morbidity, especially in women with a history of caesarean sections. We present a …

Published: Dec. 16, 2025, midnight
An integrated multimodal approach to drug repurposing in endometriosis, using ROR1 as a target.

Endometriosis is a chronic, heterogeneous disease with limited non-hormonal treatment options. Drug repurposing provides an accelerated route to identify safe, tolerable, and potentially effective therapies for endometriosis. Receptor tyrosine kinase-like …

Published: Dec. 3, 2025, midnight
High inhibition ratio and transformation index of 2 mg dienogest: further evidence for its use in endometriosis treatment.

Endometriosis is a common, chronic disease with a high burden for women, characterised by the implantation of endometrial cells outside the uterus. Many different treatments have been proposed for this …

Published: Dec. 2, 2025, midnight
Patient-derived epithelial cell organoids mimic the phenotypic complexity of endometriosis subtypes.

Can patient-derived organoid models be reliably established from diverse surgical phenotypes of endometriosis, and how do clinical factors such as hormonal treatment affect their growth success and morphology?

Published: Nov. 27, 2025, midnight
Lack of Scientific Evidence for the Use of Gestrinone in the Treatment of Lipedema: A Systematic Review.

Lipedema is a chronic, progressive disorder marked by the abnormal accumulation of subcutaneous adipose tissue, predominantly in the lower body and almost exclusively affecting women. In recent years, the off-label …

Published: Nov. 19, 2025, midnight
Analysis of Risk Factors Associated With Persistent Noncyclic Pelvic Pain Despite Hormonal Treatment in Patients With Endometriosis.

To identify risk factors that predict the persistence of noncyclical pelvic pain in patients with endometriosis despite receiving hormone therapy.

Published: Nov. 9, 2025, midnight
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