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Pathogenic Properties of Human Endometriotic Epithelial Cells Require Steroid Receptor Coactivator-2.

Commonly diagnosed in reproductive-age women, endometriosis is causally linked to subfertility, infertility, and chronic pelvic pain. Although theories exist on the etiopathogenesis of endometriosis, our understanding of its cellular and …

Published: Oct. 6, 2026, midnight
E2F1 downregulation promotes lipid droplet accumulation and endometriosis development through impaired MGLL-mediated lipid mobilization.

Endometriosis is a common gynecological disease in which lipid metabolic dysregulation has been increasingly implicated. However, the specific metabolic changes in ectopic lesions and stromal cells remain poorly understood. It …

Published: Sept. 28, 2026, midnight
Transvaginal Strain Elastography Methodology in Deep Endometriosis: Narrative Review and Proposal of a Standardized Imaging Protocol.

Transvaginal strain elastography (SE) has emerged as a complementary technique to transvaginal ultrasound for deep endometriosis (DE) evaluation by exploiting tissue stiffness between lesions and surrounding structures. However, its clinical …

Published: Sept. 28, 2026, midnight
Machine learning-assisted design of a novel crocin-loaded poloxamer 407/hyaluronic acid in situ forming hydrogel for endometriosis treatment: in vitro characterization and in vivo efficacy evaluation.

Our study focused on fabricating and characterizing a crocin in situ forming hydrogel for endometriosis treatment. An artificial neural network (ANN)-based machine learning (ML) approach was employed to determine the …

Published: Sept. 28, 2026, midnight
Accessory cavitated uterine mass presenting as refractory dysmenorrhoea: a diagnostic challenge.

A woman in her 20s presented with severe progressive dysmenorrhoea that began within 1-2 years of menarche, was refractory to medical therapy and required repeated emergency department visits for parenteral …

Published: Sept. 24, 2026, midnight
Cancer-associated mutations in endometriosis reframe a benign disease through molecular oncology.

Endometriosis is a benign yet debilitating condition, and its molecular complexity remains unexplored. Although clinically recognized, its genetic landscape has long been overlooked. This review analyses cancer-associated mutations (CAMs) identified …

Published: Sept. 23, 2026, midnight
YTHDF3 promotes angiogenesis in endometriosis by enhancing the translation efficiency of PFKFB3.

Angiogenesis plays a critical role in the progression of endometriosis, with enhanced glycolysis accelerating pathological angiogenesis. Prior research has identified a central role for N6-methyladenosine (m6A) modification in regulating glycolytic …

Published: Sept. 23, 2026, midnight
Arimoclomol-loaded Pluronic F127 nanomicelles in experimental endometriosis: drug incorporation, in vitro release, and early morphological and histological responses.

Endometriosis is a chronic, estrogen-dependent inflammatory disease characterized by ectopic endometrial-like glands and stroma, persistent pelvic inflammation, pain, infertility, and frequent recurrence. The limited availability of nonhormonal and lesion-directed therapies …

Published: Sept. 23, 2026, midnight
Establishment of pathology-validated immortalized patient-derived ovarian endometriosis epithelial cell line.

Endometriosis is a heterogeneous gynecological disorder for which experimental model development is often limited by diagnostic ambiguity and the restricted lifespan of primary epithelial cultures. Although immortalization strategies enable long-term …

Published: Sept. 23, 2026, midnight
Obstetric and Neonatal Outcomes in Deep Infiltrating Versus Superficial Endometriosis: A Retrospective Cohort Study.

To compare obstetric and neonatal outcomes between women with surgically confirmed deep infiltrating endometriosis (DIE) and superficial endometriosis, focusing on lesion-specific risk profiles. This retrospective cohort study included women with …

Published: Sept. 21, 2026, midnight
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