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Polyphenols as Modulators of Oxidative Stress and Inflammation in Endometriosis: Molecular Mechanisms and Clinical Perspectives.

Endometriosis, a chronic inflammatory condition affecting up to 10% of reproductive-age individuals, is characterized by the presence of endometrial-like tissue outside the uterine cavity. Current treatments are based primarily on …

Augmented Reality, Mixed Reality, Computer Vision, and Three-Dimensional Modeling in Fertility-Preserving Minimally Invasive Gynecologic Surgery: A Scoping Review with Narrative Synthesis.

Background and Objectives: Augmented reality (AR), mixed reality (MR), computer vision, artificial intelligence (AI), and three-dimensional (3D) modeling may be particularly relevant in fertility-preserving gynecologic surgery, where disease must be …

Anogenital distance as a biomarker for endometriosis in adolescents: a prospective, matched case-control study.

To determine whether anogenital distance (AGD), a potential non-invasive biomarker reflecting prenatal androgen exposure, differs between adolescents with laparoscopically confirmed endometriosis and matched controls.

Risk factors for intraoperative adhesion in ovarian endometriosis patients: A retrospective study.

Endometriosis is a common gynecological disease that can cause pelvic adhesions. Severe adhesions increase the difficulty of surgery, resulting in prolonged operation time, increased intraoperative bleeding, and increased complications such …

Aetiology of pelvic neuropathies in women: a narrative review.

Pelvic neuropathy is an under-recognised contributor to chronic pelvic pain in women, yet a structured overview of its identifiable causes has been lacking. In this narrative review we searched PubMed, …

Progesterone receptor modulators for endometriosis.

Endometriosis is defined as the presence of endometrium-like tissue developing outside the uterine cavity. This condition is oestrogen-dependent and thus is seen primarily during the reproductive years. Owing to their …

Correction to: Deciphering the Role of ZEB1 as a Central Regulator of Epithelial-Mesenchymal Transition and Hormonal Resistance in Endometriosis.

Liriodendrin alleviates endometriosis via PPARγ activation and inhibition of NLRP3 inflammasome-mediated pyroptosis.

Excessive activation of inflammatory responses and oxidative stress plays a critical role in the pathophysiology of endometriosis (EMs), which is characterized by ectopic lesion growth and chronic pelvic pain. However, …

A coupled iron-hypoxia selection model for the evolution of endometriosis-associated ovarian clear cell carcinoma.

Ovarian clear cell carcinoma (OCCC) frequently arises in association with endometriosis and is characterized by iron-rich oxidative stress, hypoxia-responsive metabolic reprogramming, glycogen accumulation, and alterations in ferroptosis-regulatory pathways. Interactions among …

The microbiome-inflammasome axis in endometriosis-associated chronic pelvic pain: mechanisms and therapeutic opportunities from an immunological perspective.

Endometriosis (EMs) is increasingly recognized as a chronic inflammatory disease in which innate immune dysregulation plays an important role. Its immunopathological features include macrophage polarization imbalance, with M1-skewed activation in …