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Emerging roles and therapeutic potential of tRNA-Derived small RNAs in reproductive system diseases: a review.

tRNA-derived small RNAs (tsRNAs) are a class of non-coding RNAs(ncRNAs) generated from precursor or mature tRNAs under stress conditions, such as starvation, hypoxia, or oxidative stress. They are broadly classified …

Published: Dec. 3, 2025, midnight
The role of pharmacotherapy in the treatment of endometriosis: an update.

Endometriosis is a chronic inflammatory condition affecting ~10% of reproductive-age individuals and contributing significantly to infertility, pain, and reduced quality of life. Since our 2020 review, new pharmacologic strategies, updated …

Published: Dec. 2, 2025, midnight
ZMIZ1 and estrogen receptor α form an essential partnership in endometrial biology.

Estrogen receptor α (ESR1) is a pivotal regulator of endometrial homeostasis and reproductive function, yet the coregulators that fine tune its transcriptional activity remain incompletely defined. In this issue of …

Published: Dec. 1, 2025, midnight
Transcriptional coregulator ZMIZ1 modulates estrogen responses that are essential for healthy endometrial function.

Estrogen is a critical regulator of endometrial health. Aberrant estrogen stimulation can result in infertility, endometrial cancer, and endometriosis. Here, we identified Zinc Finger MIZ-Type Containing 1 (Zmiz1) as a …

Published: Dec. 1, 2025, midnight
The value of 4-dimensional hysterosalpingo-contrast sonography in predicting the possibility of spontaneous conception in infertile women.

Some infertile women can undergo spontaneous conception after 4-dimensional hysterosalpingo-contrast sonography (4D-HyCoSy). However, advised period of expectant management after HyCoSy for different tubal patency was rarely recorded. This study aimed …

Published: Dec. 1, 2025, midnight
From Mice to Primates: Assessing Hormone-Based Endometriosis Models for Preclinical and Therapeutic Insights.

Endometriosis, a complex gynecological disorder characterized by ectopic endometrial-like tissue, affects over 10% of women, causing chronic pain and infertility. Despite extensive research, its pathophysiology remains incompletely understood, with proposed …

Published: Dec. 1, 2025, midnight
Expert transvaginal ultrasound is determinant for diagnosing pelvic conditions after recurrent implantation failure in IVF.

Recurrent implantation failure (RIF) is a clinical phenomenon characterized by a lack of implantation after several embryo-transfers. The aim of this study was to evaluate missing pelvic pathologies in patients …

Published: Dec. 1, 2025, midnight
Uterine artery S/D ratio and serum CA125 as predictors of early pregnancy loss in women with ovarian endometriomas: a retrospective case-control study.

Endometriosis affects approximately 10% of women of reproductive age and is associated with increased risks of infertility and miscarriage. Although the spontaneous miscarriage rate in women with endometriosis is higher …

Published: Nov. 29, 2025, midnight
Patients' knowledge, attitudes, and practices concerning endometriosis and its long-term management.

Endometriosis, affecting 10-15% of women, causes pain and infertility. Current treatments have limitations. This study aimed to investigate patients' knowledge, attitude, and practice (KAP) concerning endometriosis and its long-term management.

Published: Nov. 28, 2025, midnight
Robot-assisted versus standard laparoscopic approach of total hysterectomy for deep infiltrating endometriosis and adenomyosis (ENDORAS TRIAL): study protocol for a randomised controlled trial.

Endometriosis affects 5-10% of women during reproductive years, with a 20-30% incidence among those with infertility. Deep infiltrating endometriosis (DIE) affects 10-15% of women of childbearing age and 50% of …

Published: Nov. 28, 2025, midnight
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