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The Molecular and Cellular Mechanisms of Endometriosis: From Basic Pathophysiology to Clinical Implications.

Endometriosis is a complex gynecological disorder characterized by endometrial-like tissue growing outside the uterus, leading to chronic pain, infertility, and reduced quality of life. Its pathophysiology involves genetic, epigenetic, immune, …

Published: March 10, 2025, midnight
[Preliminary discussion on transumbilical laparoendoscopic single-site surgery for abdominal wall endometriosis lesion resection].

Objective: To investigate the effectiveness, safety and feasibility of transumbilical laparoendoscopic single-site surgery (TU-LESS) for abdominal wall endometriosis (AWE) lesion resection. Methods: A total of 11 patients who underwent AWE …

Published: Feb. 28, 2025, 12:10 a.m.
Smooth endoplasmic reticulum aggregates in human oocytes are related to female infertility etiology and diminished reproductive outcomes.

Smooth endoplasmic reticulum aggregates (SERa) are a type of dysmorphism in oocytes derived from controlled ovarian stimulation (COS). The effect of SERa on assisted reproductive techniques (ART) outcomes is debatable. …

Published: Feb. 28, 2025, midnight
The Role of Adenogenesis Factors in the Pathogenesis of Endometriosis.

Endometriosis is a pathological condition characterized by the presence of the endometrial tissue, outside the uterine cavity. It affects nearly 10% of women of reproductive age and is responsible for …

Published: Feb. 27, 2025, midnight
Patterns of associations with epidemiologic factors by high grade serous ovarian cancer gene expression subtypes.

Ovarian high-grade serous carcinomas (HGSC) comprise four distinct molecular subtypes based on mRNA expression patterns, with differential survival. Understanding risk factor associations is important to elucidate the etiology of HGSC. …

Published: Feb. 26, 2025, midnight
Deciphering the Role of Circulating miRNAs in the Etiology and Pathophysiology of Endometriosis: An Updated Compiled Review.

Endometriosis is characterized by the presence of endometrial tissue outside of the uterus. It is a benign chronic condition with incapacitating symptoms like infertility and pelvic pain. Endometriosis has a …

Published: Feb. 25, 2025, midnight
Primary Low-Grade Endometrial Stromal Sarcoma of the Ovary Arising From Endometriosis: A Case Report.

Low-grade endometrial stromal sarcoma (LGESS) is a rare mesenchymal tumor of female genital tract malignancies. While it primarily arises in the uterus, extrauterine cases, including those originating in the ovary, …

Published: Feb. 23, 2025, midnight
Analyzing the association between menstrual coitus and endometriosis' pathogenesis: A narrative review.

Across studies, the percentage of individuals reporting regularly engaging in menstrual coitus ranges between 4% and 43%. Although no clinical guideline recommends avoiding sexual activity during menstruation, according to some …

Published: Feb. 21, 2025, 12:26 a.m.
Rectal Endometriosis-Associated Adenocarcinoma: A Rare Entity Demanding Clinical Vigilance.

Endometriosis may become malignant, and its diagnosis is challenging, especially in rare extra-ovarian sites like the rectum. Here, we describe the case of a 42-year-old woman who presented with intermittent …

Published: Feb. 7, 2025, midnight
Multiple lesion inductions intensify central sensitization driven by neuroinflammation in a mouse model of endometriosis.

Endometriosis is an inflammatory disease associated with chronic pelvic pain (CPP). Growing evidence indicates that endometriotic lesions are not the sole source of pain. Instead, central nervous system (CNS) dysfunction …

Published: Jan. 24, 2025, midnight
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