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Bioactive Compounds and Mechanistic Insights of Chuanxiong Rhizoma and Angelicae Sinensis Radix in Endometriosis Treatment: A Network Pharmacology and Experimental Validation Study.

Endometriosis, a chronic gynecological disorder, significantly impacts fertility and quality of life. Identifying effective therapeutic targets is critical for their management.

Published: June 8, 2026, midnight
The Endometriosis Pain Course: exploring predictors of clinical response to an internet-delivered psychological pain management program for endometriosis.

Emerging research indicates the potential of psychological pain management programs to address disability and distress associated with endometriosis-related pain. Understanding the characteristics of patients likely to benefit from such programs …

Published: June 8, 2026, midnight
Anti-NRP1 peptide-engineered ROS/pH dual-responsive nanoparticles for Alpelisib delivery regulate Sema3A-NRP1/PI3K-AKT signaling to balance oxidative stress and inhibit angiogenesis in endometriosis.

Endometriosis progression is driven by oxidative stress and excessive angiogenesis within an inflammatory microenvironment. To overcome these challenges, we designed ROS/pH dual-responsive Alpelisib-loaded nanoparticles (Alp@TAT-AT7-NPs) functionalized with an anti-NRP1 peptide …

Published: June 6, 2026, midnight
Out of pocket expenditure incurred by couples seeking infertility services at tertiary level facilities in India.

Background and objectives Diagnosis and treatment of infertility, mostly sought at tertiary facilities, contribute to substantial out-of-pocket expenditure (OOPE). This study estimated OOPE among couples seeking care for endometriosis, male …

Published: June 5, 2026, midnight
Gut microbiota dysbiosis in endometriosis: mechanistic insights and gut microbiota-targeted therapeutic strategies.

Endometriosis (EMs) is a prevalent, estrogen-dependent gynecological disorder characterized by the ectopic implantation and proliferation of endometrial-like tissue outside the uterine cavity, affecting approximately 10% of reproductive-aged women globally. Despite …

Published: June 5, 2026, midnight
Mesonephric-like adenocarcinoma as an unexpected histological result after fertility saving procedure for presumed adenomyosis: a case report.

We report an unexpected case of mesonephric-like adenocarcinoma initially treated as a diffuse adenomyosis in a patient presenting with primary infertility. The aim of this report is to raise clinical …

Published: June 5, 2026, midnight
Deep Dyspareunia One Year After Nerve-Sparing Endometriosis Surgery: An Observational Study Highlighting Undesirable Outcomes.

Background/Objectives: This study evaluates the 1-year follow-up outcomes after minimally invasive nerve-sparing surgery for the complete excision of deep endometriosis (DE), with a specific focus on deep dyspareunia. Cases with …

Published: June 5, 2026, midnight
Hypoxia-induced regulations of cell adhesion molecules and their implications for pathogenesis, diagnosis, and treatment of endometriosis.

Endometriosis is a chronic inflammatory disease characterized by the presence of endometrial-like tissue outside the uterine cavity, affecting up to 10% of women of reproductive age. Despite extensive research, its …

Published: June 4, 2026, midnight
MGST3 Promotes Endometriosis Progression by Suppressing Ferroptosis.

Endometriosis (EMs) is characterized by dysregulated persistence and enhanced invasiveness of ectopic endometrial cells. Current treatment strategies remain limited by high recurrence rates and considerable adverse effects. Although iron overload …

Published: June 3, 2026, midnight
In the River.

This prose poem explores a nonbinary and transmasculine experience with total hysterectomy salpingectomy/ooporectomy as a gender-affirming procedure as well as treatment for stage four endometriosis, polycystic ovarian syndrome, and multiple …

Published: June 3, 2026, midnight
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