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Identification of Candidate Genes for Endometriosis in a Three-Generation Family with Multiple Affected Members Using Whole-Exome Sequencing.

Background: Endometriosis is a chronic inflammatory condition affecting 10-15% of women of reproductive age. Genome-wide association studies (GWASs) have accounted for only a fraction of its high heritability, indicating the …

Published: Aug. 6, 2025, midnight
Recurrent Hemothorax and Hemoperitoneum in Endometriosis: A Case Report.

Extra-pelvic endometriosis, defined as the presence of endometrial tissue or stroma outside of the pelvic cavity, is a rare cause of hemothorax and hemoperitoneum. Here, we present a case of …

Published: Aug. 6, 2025, midnight
Epithelial characteristics of ovarian clear cell carcinoma at single-cell resolution.

Ovarian clear cell carcinoma (OCCC) represents a rare and aggressive subtype of epithelial ovarian cancer with distinctive clinical and molecular characteristics. However, the identification, origin, and molecular features of the …

Published: Aug. 5, 2025, midnight
Gynecologic postoperative anti-adhesion barriers: From biomaterials to barrier development.

Gynecologic postoperative adhesions (GPOA) remain an under-appreciated source of morbidity despite advances in minimally invasive surgery. Adhesions forming after myomectomy, extensive endometriosis excision, repeat caesarean section, or hysteroscopic adhesiolysis develop …

Published: Aug. 5, 2025, midnight
Endometrial regeneration and the role of the extracellular matrix: mechanisms, challenges, and future perspectives.

Endometrial regeneration is a cornerstone of reproductive health, with the extracellular matrix (ECM) playing a pivotal role in tissue repair, regeneration, and fertility restoration. Dysregulated ECM remodeling is at the …

Published: Aug. 5, 2025, midnight
Design of a peripherally biased NPSR1 antagonist for neuropeptide S induced inflammation.

Neuropeptide S (NPS) is a potent agonist for the GPCR receptor NPSR1, implicated in various physiological and pathological processes, including inflammation. NPSR1 gene polymorphisms have been linked to asthma, inflammatory …

Published: Aug. 5, 2025, midnight
Management of uterine artery pseudoaneurysm: a case report of noninterventional treatment with systematic review.

Uterine artery pseudoaneurysm (UAP) is a rare but potentially life-threatening condition that can result in severe hemorrhage. Due to its nonspecific clinical presentation, it is often misdiagnosed, leading to delays …

Published: Aug. 5, 2025, midnight
From pelvis to heart: A rare case of infective endocarditis following ASD device closure due to tubo-ovarian abscess.

Infective endocarditis (IE) following transcatheter atrial septal defect (ASD) device closure is a rare but life-threatening complication. We report a case of a 41-year-old woman who developed device-related IE five …

Published: Aug. 5, 2025, midnight
Ovulatory follicular fluid promotes the clonogenicity and invasion of ectopic and eutopic endometrial cells.

Endometriosis is a chronic, estrogen-dependent disorder characterized by the ectopic growth of endometrial-like tissue. Despite its significant impact on fertility and quality of life, the pathogenesis of endometriosis remains poorly …

Published: Aug. 4, 2025, midnight
Laparoscopic ovarian drilling (LOD) versus Step-up gonadotropin therapy in infertile anovulatory PCOS women resistant to sequential letrozole and gonadotropin-based ovulation induction cycles: a randomized controlled trial.

To study the effect of laparoscopic ovarian drilling (LOD) versus step-up gonadotropin therapy on follicular response in infertile anovulatory PCOS women resistant to sequential Letrozole + HMG (Human Menopausal Gonadotropin) …

Published: Aug. 2, 2025, midnight
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