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How transcription factors regulate apoptosis in endometriosis (Review).

Endometriosis (EM) is a common chronic gynaecological disease that affects 10% of women of reproductive age globally. EM is defined as the presence of endometrial glands and stroma in extrauterine …

Published: Aug. 24, 2025, midnight
MMP2/TIMP2 ratio as a measurable indicator for differentiating diffuse adenomyosis, ovarian endometriosis, and their co-existence.

Adenomyosis and endometriosis, two common estrogen-dependent benign gynecological disorders usually present with overlapping symptoms, such as pain and infertility. These two conditions often co-exist and are associated with poor reproductive …

Published: Aug. 24, 2025, midnight
3D map-guided modeling of functional endometrial tissue using multi-compartment assembloids.

The human endometrium is a dynamic tissue that lines the uterus and undergoes constant remodeling, making it especially susceptible to gynecological diseases like endometriosis and endometrial cancer. The molecular mechanisms …

Published: Aug. 23, 2025, midnight
Expression profiles of E-cadherin and N-cadherin in endometriosis and other gynecological diseases towards targeted treatment: a systematic review.

This systematic review aimed to summarize all available data and evaluate the roles of E-cadherin, N-cadherin, associated molecules, and signaling pathways in the pathogenesis of endometriosis. The search was conducted …

Published: Aug. 21, 2025, midnight
H3K27me3-mediated epigenetic regulation of TET1 in the eutopic endometrium of women with endometriosis and infertility.

Endometriosis is a common gynecological condition associated with chronic inflammation, epigenetic dysregulation, and infertility. The TET1 gene, involved in DNA demethylation, may be regulated by repressive histone modifications such as …

Published: Aug. 10, 2025, midnight
Integrated transcriptomic and proteomic analysis reveals that the anti-endometriosis effects of Pingchong Jiangni recipe may involve pathways and genes/proteins related to inflammation, autophagy, mitochondrial function, and angiogenesis in ectopic endometrial stromal cells.

Pingchong Jiangni recipe (PJR) is a Chinese herbal formula that has been used clinically for decades in the treatment of endometriosis, with effects such as shrinking the lesions and reducing …

Published: Aug. 5, 2025, midnight
Endometrial regeneration and the role of the extracellular matrix: mechanisms, challenges, and future perspectives.

Endometrial regeneration is a cornerstone of reproductive health, with the extracellular matrix (ECM) playing a pivotal role in tissue repair, regeneration, and fertility restoration. Dysregulated ECM remodeling is at the …

Published: Aug. 5, 2025, midnight
Impaired Decidualization and Angiogenesis in Eutopic Endometrium of Endometriosis: Insights from In Vitro Models.

Endometriosis markedly compromises female fertility, and although endometrial dysfunction likely plays a role in this pathology, its precise mechanistic contributions remain poorly understood. This study aims to investigate the decidualization …

Published: Aug. 1, 2025, midnight
Microplastic exposure induces epithelial barrier alterations and increases collagen deposition in a 3D human endometrial model in vitro.

To investigate the effects of microplastics (MPs) on the human endometrium in vitro.

Published: Aug. 1, 2025, midnight
Comparison of the Efficacy of Single vs. Double Autologous Platelet-Rich Plasma (PRP) Intrauterine Infusion on Endometrial Receptivity in Thin Endometrium Patients: A Prospective Randomized Controlled Trial - Frontiers

Comparison of the Efficacy of Single vs. Double Autologous Platelet-Rich Plasma (PRP) Intrauterine Infusion on Endometrial Receptivity in Thin Endometrium Patients: A Prospective Randomized Controlled Trial Frontiers

Published: July 30, 2025, 7:34 p.m.
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