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Glycolytic reprogramming and MYH10 K1520 lactylation mediate eutopic endometrial collagen I deposition driven by PKM2-packaged ectopic endometrial extracellular vesicles.

Endometriosis (EMs) is characterized by ectopic lesions that disrupt endometrial decidualization, a process frequently accompanied by aberrant collagen deposition and closely linked to clinical infertility. Extracellular vesicles (EVs) are key …

Published: May 11, 2026, midnight
Efficacy and Safety of Elagolix Versus Dienogest for Treatment of Moderate-to-Severe Endometriosis Pain: A Phase III, Multicentric, Double-Blind, Active-Controlled, Non-Inferiority Study.

To compare the efficacy, safety and tolerability of elagolix with dienogest in women with moderate-to-severe endometriosis-associated pain.

Published: May 11, 2026, midnight
Negative impacts of ovarian endometrioma on preantral follicle development: implications for endometriosis-related infertility.

Endometriosis is a chronic, estrogen-dependent inflammatory disorder and a leading cause of female infertility. Ovarian endometriomas, a common manifestation of endometriosis, are commonly associated with diminished ovarian function; however, the …

Published: May 11, 2026, midnight
[Catamenial Pneumothorax During Endometriosis Treatment].

Here, we report a case of catamenial pneumothorax that occurred during endometriosis treatment. A 46-year-old woman presented with a history of right pneumothorax. At 43 years of age, the patient …

Published: May 9, 2026, midnight
Somatic mutations in endometrial epithelium: biological insights and emerging in vitro models.

The human endometrium is a complex, dynamic and poorly understood tissue involving monthly cyclical regeneration likely from adult stem/progenitor cells. This regeneration is associated with reproductive pathologies, such as endometriosis …

Published: May 9, 2026, midnight
Primary Periumbilical Endometriosis Mimicking Umbilical Hernia in a 37-Year-Old Woman: A Report of a Rare Case.

This case report describes a rare presentation of primary periumbilical endometriosis, also known as Villar's nodule, highlighting the diagnostic difficulties and the importance of maintaining clinical suspicion. A 37‑year‑old woman …

Published: May 9, 2026, midnight
Mortality risk associated with endometriosis: a systematic review and meta-analysis.

Endometriosis is a chronic, estrogen-dependent gynecological disorder affecting approximately 10% of women worldwide that can cause pelvic pain, lead to infertility, and impair quality of life. Whether the condition elevates …

Published: May 8, 2026, midnight
Neutrophil-to-lymphocyte ratio (nlr) as a predictor of endometriosis occurrence and prognosis: Evidence from a single-center study in Indonesia.

Endometriosis is a chronic inflammatory condition characterized by the presence of endometrial tissue outside the uterus, leading to pelvic pain and infertility. It affects approximately 10% of women of reproductive …

Published: May 8, 2026, midnight
Selected Parameters of the Mental State of Women with Endometriosis-A Systematic Review.

Background: Endometriosis is a chronic, estrogen-dependent inflammatory disorder affecting millions of women worldwide and constitutes a major cause of chronic pelvic pain and reduced quality of life. Increasing evidence suggests …

Published: May 8, 2026, midnight
Dose-Dependent Reprogramming of Chromatin Accessibility by SOX4 Drives the Transcriptional Response to Iron Overload.

Iron overload induces cellular stress and is implicated in diverse pathological conditions. Nevertheless, the epigenetic mechanisms governing mammalian cellular responses to iron overload remain poorly characterized. Using multi-omics profiling in …

Published: May 7, 2026, midnight
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