Endometriosis is a chronic, estrogen-dependent inflammatory disease characterized by the ectopic presence of endometrial-like tissue. Although genome-wide association studies (GWAS) have identified susceptibility variants, their tissue-specific regulatory impact remains poorly …
Background: Endometriosis is a chronic inflammatory condition affecting 10-15% of women of reproductive age. Genome-wide association studies (GWASs) have accounted for only a fraction of its high heritability, indicating the …
Evidence regarding risk for hysterectomy following treatment for benign gynecological conditions with a Levonorgestrel-releasing intrauterine device (LNG-IUD) is limited. We assess whether race and ethnicity are associated with hysterectomy risk …
To test, among women with natural menopause, whether: infertility, miscarriage, stillbirth, and low parity are associated with a higher risk of osteoporosis; menopause age can partly explain their associations.
Endometriosis has been linked to several systemic complications, including cardiovascular disease (CVD), atrial fibrillation (AF), heart failure (HF), hypertension, stroke, and ischemic stroke. The potential causal relationship between endometriosis and …
This study investigated the role of ACSL4 in endometrial receptivity disorders in endometriosis (EMs) and evaluated PRGL493, an ACSL4 inhibitor, as a potential therapeutic target. Bioinformatic analysis identified ACSL4 as …
Background: Endometriosis is a chronic condition that affects the endometrium, the lining of the uterus. The endometrium typically thickens and discharges during the menstrual cycle, resulting in menstruation. Endometriosis is …
Endometriosis is a chronic estrogen-dependent gynecological disease affecting millions of women worldwide. Besides its well-established impact on reproductive health, emerging evidence suggests a potential association between endometriosis and periodontal disease. …
Endometriosis is a common disease for women of reproductive ages. Individuals with accelerated biological aging are at a higher risk of developing various diseases, however, the effect of biological aging …