Peritoneal Hypoxia as a Gatekeeper Between Physiologic Retrograde Menstruation and Pathologic Persistence in Endometriosis.
Several hypotheses have been proposed to explain the establishment of endometriosis, of which retrograde menstruation remains the most widely accepted mechanism of dissemination. However, the mechanisms governing selective lesion establishment …
Glycolytic reprogramming and MYH10 K1520 lactylation mediate eutopic endometrial collagen I deposition driven by PKM2-packaged ectopic endometrial extracellular vesicles.
Endometriosis (EMs) is characterized by ectopic lesions that disrupt endometrial decidualization, a process frequently accompanied by aberrant collagen deposition and closely linked to clinical infertility. Extracellular vesicles (EVs) are key …
Response to the Letter: Observations and points of interest regarding bioinformatics predictions of miRNA targeting syncytin genes in endometriosis and miscarriage.
Insights from an observational matched case-control study on the association between endometriosis and benign uterine disorders in infertile patients.
The link between endometriosis and other medical conditions is gaining attention. Such insights could enhance clinical approaches to manage the disease and potentially reveal new, unrecognized mechanisms of its development. …
Somatic mutations in endometrial epithelium: biological insights and emerging in vitro models.
The human endometrium is a complex, dynamic and poorly understood tissue involving monthly cyclical regeneration likely from adult stem/progenitor cells. This regeneration is associated with reproductive pathologies, such as endometriosis …
FGFR2-responsive self-assembled hydrogel releases its inhibitor to suppress the progression of endometriosis.
Fibroblast growth factor receptor 2 (FGFR2) has emerged as a highly promising therapeutic target due to its critical role in the pathogenesis and progression of endometriosis. To date, a variety …
Clear cell carcinoma arising from abdominal wall endometriosis: A case report with imaging findings and pathologic correlation.
Clear cell carcinoma arising from abdominal wall endometriosis is an exceptionally rare malignancy that typically develops at prior surgical scar sites. We report a case of a woman in her …