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Addressing Meta-Inflammation in the Comprehensive Management of Chronic Pain.

Chronic pain is a widespread condition affecting millions globally, placing significant strain on healthcare systems, as evidenced by the current opioid crisis. Despite advances in pain management, conventional treatments often …

Published: Oct. 18, 2025, midnight
Fibroblast heterogeneity and FN1-mediated signaling in endometriosis revealed by single-cell and spatial transcriptomics.

Endometriosis (EM) is a chronic gynecological disorder that affects 5% to 10% of women of childbearing age, often causing pelvic pain and infertility. Fibrosis is a hallmark of EM progression, …

Published: Oct. 13, 2025, midnight
Two Cases of Mesonephric-Like Adenocarcinoma Arising From Ovary and Peritoneal and Literature Review.

Reports of Mesonephric-like adenocarcinoma (MLA) arising from other than the ovary and uterus are exceedingly rare. This report details two cases of MLA in patients with a history of endometriosis. …

Published: Oct. 12, 2025, midnight
Plant-based bioactives and oxidative stress in reproduction: anti-inflammatory and metabolic protection mechanisms.

Oxidative stress plays a central role in reproductive disorders, with food bioactive compounds offering therapeutic potential through their antioxidant properties. This review examines antioxidant active ingredients from plant-based foods and …

Published: Oct. 9, 2025, midnight
Polychlorinated Biphenyls Alter Estrogen Receptor beta-Mediated Epigenetic Regulation, Promoting Endometriosis.

Endometriosis is a pathological condition characterized by the ectopic growth of endometrial cells, leading to chronic pelvic pain and infertility. Epidemiological studies have associated exposure to dioxin-like polychlorinated biphenyls (PCBs), …

Published: Oct. 7, 2025, midnight
Impact of endocrine disruptors on female fertility: an update.

Endocrine disruptors (EDs) are a heterogeneous group of natural or synthetic chemicals capable of interfering with hormonal regulation. Widely present in plastics, cosmetics, pesticides, food packaging, and household products, they …

Published: Oct. 7, 2025, midnight
Extracellular granzyme B and K are associated with endometriosis severity in infertile women.

Endometriosis is a chronic inflammatory condition often associated with infertility. The role of granzymes as cytotoxic proteases and immune regulators in endometriosis remains poorly understood. This study evaluated serum and …

Published: Oct. 4, 2025, midnight
Psychological, Symptom-Related, and Lifestyle Predictors of Health-Related Quality of Life in Hungarian Women with Endometriosis.

Background: This study was a cross-sectional online survey aimed at examining health-related quality of life and the effect of different symptoms and lifestyle factors on health-related quality of life in …

Published: Oct. 3, 2025, midnight
Psychological factors mediate the relationship between trauma exposure and pain intensity in women with endometriosis: a cross-sectional study.

Endometriosis, a chronic inflammatory condition often characterized by chronic pelvic pain, significantly impacts women's quality of life. While psychological distress, including depression and anxiety, is prevalent in women with endometriosis, …

Published: Sept. 29, 2025, midnight
Resection of Bilateral Endometriosis of the Uterosacral Ligaments Resolves Voiding Dysfunction: A Case Report.

Patients with deep endometriosis of the posterior pelvic compartment might present various lower urinary tract symptoms, including urinary retention, without any prior pelvic surgery in their medical history. These symptoms, …

Published: Sept. 29, 2025, midnight
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