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IGF2BP1 promotes endometriosis by enhancing m6A modification stability of HMGB1.

Endometriosis is a chronic inflammatory condition afflicting women of reproductive age. Our study aims to clarify the function and mechanism of insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) and …

Published: Feb. 20, 2025, 12:06 a.m.
Correction: A rare case of concomitant endometrioid adenocarcinoma arising from uterine adenomyosis and clear cell carcinoma arising from parametrial deep endometriosis.

Published: Feb. 20, 2025, midnight
Identification of potential diagnostic biomarkers and drug targets for endometriosis from a genetic perspective: a mendelian randomization study.

Endometriosis (EM) is a chronic disease severely impacting reproductive health, with its exact cause still unclear. In-depth understanding of the etiology and pathogenesis of EM from the perspective of genetics …

Published: Feb. 20, 2025, midnight
COVID-19 and our understanding of vitamin D and immune function.

The interaction between vitamin D and the immune system is perhaps the most well recognised extraskeletal facet of vitamin D, encompassing early studies of therapy for TB and leprosy through …

Published: Feb. 20, 2025, midnight
Association of Sleep Traits, Physical Activity, and Sedentary Leisure Behavior With Female Reproductive Health: A Two-Sample Mendelian Randomization Analysis.

Living habits affect female endocrine function and fertility, along with aging and other life factors. Because of this, female reproductive health can be promoted through living habit adjustment.

Published: Feb. 20, 2025, midnight
PARP-2 acts on ILK signaling and pharmacological targeting of PARP-2 ameliorate endometriosis in a mouse model.

Endometriosis, an endocrine disorder in reproductive-aged women with an occurrence of ∼10 %, gives rise to inflammation, pelvic pain, menstrual irregularity, infertility, etc. One study demonstrated the elevated plasma level …

Published: Feb. 20, 2025, midnight
Diagnostic Accuracy of Transvaginal Ultrasonography for Endometriosis According to the International Deep Endometriosis Analysis Consensus.

To evaluate the diagnostic accuracy of transvaginal ultrasonography (TVUS) in detecting deep endometriosis, ovarian endometriosis, and superficial endometriosis using the IDEA (International Deep Endometriosis Analysis) consensus and novel International Terminology …

Published: Feb. 20, 2025, midnight
The Role of Psychologists in Treating Pelvic Pain Conditions.

Patients with pelvic floor disorders may experience a wide range of symptoms affecting one or more compartments of the pelvic floor (anterior/urinary, apical/reproductive, and posterior/gastrointestinal). Disorders affecting the pelvic organs …

Published: Feb. 20, 2025, midnight
A Fibronectin (FN)-Silk 3D Cell Culture Model as a Screening Tool for Repurposed Antifibrotic Drug Candidates for Endometriosis.

This study advances sustainable pharmaceutical research for endometriosis by developing in vitro 3D cell culture models of endometriotic pathophysiology that allow antifibrotic drug candidates to be tested. Fibrosis is a …

Published: Feb. 19, 2025, midnight
Exploring macrophage and nerve interaction in endometriosis-associated pain: the inductive role of IL-33.

Endometriosis, a persistent inflammatory disease, is associated with pelvic or abdominal pain. The immune system and sensory nervous system show a synergistic effect on regulation of pain. In particular, Interleukin-33 …

Published: Feb. 19, 2025, midnight
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