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Optimizing infertility treatment for ovarian endometrioma: is surgical intervention preferable before or after in-vitro fertilization programs?

Endometriosis is one of the common endometrial pathologies that occurs in reproductive-age women and could lead to infertility. This study set out to observe which clinical management of endometriosis with …

Published: March 5, 2025, midnight
Addressing the Endometriosis Gap and Promoting Equal Access to Care for Black Women with Endometriosis.

Published: March 5, 2025, midnight
Polygenic Scores for Dizygotic Twinning: Insights into the Genetic Architecture of Female Fertility.

Natural dizygotic twinning (DZT) results from hyper-ovulation and is considered an indicator of female fertility. DZT has low polygenicity, with only 0.20% of SNPs estimated to have a nonzero effect. …

Published: March 5, 2025, midnight
The Role of Mast Cells in the Development and Advancement of Endometriosis.

Endometriosis is a medical condition identified by the presence of endometrium-like tissue outside the uterus. This condition is known to result in symptoms such as frequent pelvic pain, infertility, and …

Published: March 4, 2025, 12:17 a.m.
Causal Relationship Between Abortion and Endometriosis: A Bidirectional Two-Sample Mendelian Randomization Study.

The relationship between abortion and endometriosis (EMS) has been inconsistent in previous observational studies and remains controversial. We intended to examine the causal relationship between abortion and EMS.

Published: March 4, 2025, 12:04 a.m.
Phosphatase and tensin homolog deficiency induces M2 macrophage polarization by promoting glycolytic activity in endometrial stromal cells.

Endometriosis is a common gynecological disorder, whose pathogenesis remains incompletely understood. Macrophages, a key type of immune cell, are pivotal in the context of endometriosis. This study seeks to explore …

Published: March 4, 2025, midnight
GRB2 regulation of essential signaling pathways in the endometrium is critical for implantation and decidualization.

Over 75% of failed pregnancies involve implantation defects. Growth factor receptor-bound protein 2 (GRB2) is an adaptor protein involved in signal transduction and cell communication. Here we show that the …

Published: March 4, 2025, midnight
MCP-1 promotes ILK phosphorylation at Ser246 during endometriosis development and affects the pregnancy outcome.

In women with endometriosis, monocyte chemoattractant protein 1 (MCP-1) or chemokine (C-C motif) ligand 2 (CCL2) is elevated in serum, peritoneal fluid, and endometriotic lesions, though its exact role in …

Published: March 4, 2025, midnight
Pain Sensitivity Questionnaire in Endometriosis.

There is increasing recognition that nociplastic pain and central sensitization may play a role in endometriosis-associated pain. The Pain Sensitivity Questionnaire Minor (PSQ-M) evaluates subjective widespread pain sensitivity, and is …

Published: March 4, 2025, midnight
10-steps laparoscopic excision for a rudimentary uterine horn.

Uterine malformations of the rudimentary horn type affect 2 to 4% of women. Resulting from a defect in the fusion of Muller's ducts, they are responsible for dysmenorrhea and lead …

Published: March 4, 2025, midnight
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