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The dual nature of immunotherapy in female reproductive disorders: immune homeostasis and clinical challenges.

The female reproductive system (FRS) exhibits unique immunological characteristics, balancing defense against pathogens with tolerance to sperm and semi-allogeneic embryos. Key players include decidual natural killer (dNK) cells, immune checkpoint …

Published: Oct. 2, 2025, midnight
Performing Endometriosis as placental dramaturgy.

Performing Endometriosis is an autopathographic piece, written and performed by VR and directed by MM (coauthors of the present article). Divided into very short scenes (called Glimpses), Performing Endometriosis is …

Published: Oct. 1, 2025, midnight
Reduced Vagal Tone in Women with Adenomyosis.

Adenomyosis is an estrogen-dependent disease featuring chronic inflammation. This study was undertaken to investigate whether the vagal tone is reduced in patients with adenomyosis as compared with healthy women. We …

Published: Sept. 30, 2025, midnight
Design and prioritization of the French surveillance program of health effects in the context of exposure to endocrine disruptors using a Delphi study.

Rapidly increasing evidence has documented that endocrine disruptors (EDs) contribute substantially to disease and disability, particularly neurodevelopmental disorders, metabolic diseases, reproductive disorders, immune and thyroid dysfunctions, as well as hormone-related …

Published: Sept. 30, 2025, midnight
The Role of Nutrition in Endometriosis Prevention and Management: A Comprehensive Review.

Endometriosis is a chronic gynecological condition defined by the ectopic presence of endometrial-like tissue outside the uterine cavity, often resulting in debilitating symptoms and significant impacts on quality of life. …

Published: Sept. 30, 2025, midnight
Psychological factors mediate the relationship between trauma exposure and pain intensity in women with endometriosis: a cross-sectional study.

Endometriosis, a chronic inflammatory condition often characterized by chronic pelvic pain, significantly impacts women's quality of life. While psychological distress, including depression and anxiety, is prevalent in women with endometriosis, …

Published: Sept. 29, 2025, midnight
Relugolix's impact on endometriosis-associated pain and quality of life: a meta-analysis of EHP-30 outcomes.

Relugolix offers a promising alternative for endometriosis-associated pain, yet its comprehensive impact on health-related quality of life (HRQoL), particularly as measured by the disease-specific EHP-30 questionnaire, remains underexplored.

Published: Sept. 29, 2025, midnight
Endometriosis Diagnostic Delay and Its Correlates: Results from the ComPaRe-Endometriosis Cohort.

Background: An average time to diagnosis of 7 years is commonly described for endometriosis; diagnostic delay for adenomyosis is unknown. This cross-sectional study aimed to describe diagnostic delay for endometriosis …

Published: Sept. 26, 2025, midnight
FIGO committee opinion: Environmental drivers of gynecologic and reproductive health.

This FIGO committee opinion paper addresses the growing body of evidence linking environmental exposures to common gynecologic and reproductive conditions across the life course. From adolescence through menopause, women are …

Published: Sept. 26, 2025, midnight
Endometriosis-associated infertility alters the microRNA signatures of cumulus cells with a particularly pronounced effect in oocytes that failed fertilization.

Endometriosis (E) is multifactorial disease affecting around 10% of women worldwide. The association between E and infertility is clinically well recognized. For E patients to achieve a successful pregnancy, assisted …

Published: Sept. 26, 2025, midnight
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