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Emerging signal transduction pathways and the role of bacterial extracellular vesicles linked to the pathogenesis of endometriosis.

Endometriosis is defined as the ectopic proliferation of endometrial cells. Aberrant signal transduction is present in ectopic endometriotic lesions, and bacteria also contributes to the development of endometriosis by transmitting …

Published: June 4, 2026, midnight
Gut-reproduction axis: genome-wide pleiotropic and prospective evidence linking inflammatory bowel disease with gynecological disorders.

We aimed to explore shared genetic architectures and potential causal associations between inflammatory bowel disease (IBD) and gynecological diseases, including ovarian cysts (OC), pelvic inflammatory disease (PID), and endometriosis (EMs), …

Published: June 4, 2026, midnight
Psychological flexibility and pain catastrophizing in endometriosis: Incremental validity and interaction effects in predicting psychosocial outcomes.

Psychological distress and reduced health-related quality of life are common among women with endometriosis, particularly when the condition is accompanied by chronic pain. Psychological flexibility (PF), a core process in …

Published: June 4, 2026, midnight
Robotic versus laparoscopic enucleation of ovarian endometriotic cysts with pathological analysis of inadvertent follicular loss.

Ovarian endometrioma cystectomy may compromise ovarian reserve through inadvertent excision of ovarian cortex. We compared inadvertent cortical removal between robotic-assisted and conventional laparoscopic cystectomy using digital pathology. We retrospectively analyzed …

Published: June 4, 2026, midnight
Deciphering the Pleiotropic Role of ARID1a and RIF1 in Endometrioid Ovarian Cancer.

Given the challenges in early detection and diagnosis, understanding the molecular underpinnings of endometrioid ovarian cancer (EOC) is crucial for improving patient outcomes. This multi-level study provides a new perspective …

Published: June 4, 2026, midnight
TICAM1-Mediated TLR3/TLR4 Signaling Promotes Endometrial Stromal Cell Proliferation, Migration, and Invasion in Endometriosis via IRF3/IFN-β Axis.

Endometriosis (EMs) is an estrogen-dependent inflammatory disease characterized by the presence of endometrial-like tissue outside the uterine cavity, yet its precise pathogenesis remains incompletely elucidated. TICAM1, a key adaptor protein …

Published: June 4, 2026, midnight
PBMC-derived FGF, PDGF, VEGF and GM-CSF secretion in endometriosis: a case-control in vitro study.

Endometriosis is a chronic inflammatory disease with immune dysregulation in which angiogenic, and hematopoietic mediators are thought to contribute to ectopic lesion establishment and persistence. Whether circulating immune cells are …

Published: June 4, 2026, midnight
Hypoxia-induced regulations of cell adhesion molecules and their implications for pathogenesis, diagnosis, and treatment of endometriosis.

Endometriosis is a chronic inflammatory disease characterized by the presence of endometrial-like tissue outside the uterine cavity, affecting up to 10% of women of reproductive age. Despite extensive research, its …

Published: June 4, 2026, midnight
Pelvic neurovascular anatomy and avascular spaces: a pictorial essay of key surgical landmarks.

A precise understanding of pelvic neurovascular anatomy is essential for minimizing complications during advanced gynecological and pelvic surgery. Retroperitoneal dissection requires a clear appreciation of spatial relationships between vascular, neural, …

Published: June 3, 2026, midnight
MGST3 Promotes Endometriosis Progression by Suppressing Ferroptosis.

Endometriosis (EMs) is characterized by dysregulated persistence and enhanced invasiveness of ectopic endometrial cells. Current treatment strategies remain limited by high recurrence rates and considerable adverse effects. Although iron overload …

Published: June 3, 2026, midnight
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