Andrographolide blocked the progression of endometriosis by promoting ferroptosis via inhibiting anabolism of serine.
Ferroptosis is a potential target for the treatment of endometriosis (EMs). The role of andrographolide (AP) in the ferroptosis has gradually attracted attention, but its mechanism of action in endometriosis …
Expression of Concern: Evaluation of CA125 in relation to pain symptoms among adolescents and young adult women with and without surgically-confirmed endometriosis.
[Immunology of fertilization, implantation and pregnancy: Key interactions and therapeutic perspectives].
The immunology of fertilization, implantation and pregnancy is based on a complex balance between maternal immune tolerance and a controlled inflammatory response. Adaptation of the maternal immune system is essential …
Prediction of microRNAs affecting the syncytin-1 (HERV-W) and syncytin-2 (HERV-FRD) genes regulation in endometriosis and miscarriage.
Abnormal expression levels of microRNAs are associated with numerous diseases in the female reproductive tract. A small subset of human endogenous retroviruses (HERVs) genes have retained open reading frames (ORFs) …
An integrated multimodal approach to drug repurposing in endometriosis, using ROR1 as a target.
Endometriosis is a chronic, heterogeneous disease with limited non-hormonal treatment options. Drug repurposing provides an accelerated route to identify safe, tolerable, and potentially effective therapies for endometriosis. Receptor tyrosine kinase-like …
Emerging roles and therapeutic potential of tRNA-Derived small RNAs in reproductive system diseases: a review.
tRNA-derived small RNAs (tsRNAs) are a class of non-coding RNAs(ncRNAs) generated from precursor or mature tRNAs under stress conditions, such as starvation, hypoxia, or oxidative stress. They are broadly classified …
Transcriptional coregulator ZMIZ1 modulates estrogen responses that are essential for healthy endometrial function.
Estrogen is a critical regulator of endometrial health. Aberrant estrogen stimulation can result in infertility, endometrial cancer, and endometriosis. Here, we identified Zinc Finger MIZ-Type Containing 1 (Zmiz1) as a …