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New therapeutic targets for endometriosis predicted through mendelian randomization analysis and case-control trials.

Endometriosis is a common chronic gynecological condition that affects approximately 10% of women of reproductive age worldwide.

Published: Aug. 15, 2025, midnight
Unveiling the vital role of OGG1 in inflammation, vascular endothelial damage, and cell death in obstetric and gynecological diseases.

The DNA repair enzyme 8-oxoguanine DNA glycosylase-1 (OGG1) plays a crucial role in the initiation of DNA base excision repair pathway by recognizing and excising the oxidative base lesions including …

Published: Aug. 14, 2025, midnight
Global, regional, and national burdens of endometriosis from 1990 to 2021: a trend analysis.

Endometriosis is a common, chronic, estrogen-dependent gynecological disorder that significantly affects patients' quality of life. However, the disease burden and its trends may be undergoing significant changes, and comprehensive data …

Published: Aug. 14, 2025, midnight
The role of TGF-β superfamily in endometriosis: a systematic review.

Endometriosis is a prevalent chronic gynecological disorder. Globally, endometriosis affects approximately 5-10% of women of reproductive age, leading to symptoms such as dysmenorrhea, chronic pelvic pain, and infertility. While the …

Published: Aug. 12, 2025, midnight
H3K27me3-mediated epigenetic regulation of TET1 in the eutopic endometrium of women with endometriosis and infertility.

Endometriosis is a common gynecological condition associated with chronic inflammation, epigenetic dysregulation, and infertility. The TET1 gene, involved in DNA demethylation, may be regulated by repressive histone modifications such as …

Published: Aug. 10, 2025, midnight
Anti‑inflammatory and anti‑migratory properties of wild‑grape‑derived ε‑viniferin in human endometrial cells:  A potential therapy for endometriosis.

Endometriosis is a chronic gynecological disorder characterized by the ectopic growth and proliferation of endometrial tissue outside the uterine cavity, leading to inflammation. Although low‑dose contraceptive pills are widely used …

Published: Aug. 8, 2025, midnight
Role of Phytoestrogens in Gynecological Disorders from the Lens of Unani System of Medicine-A Review.

In recent years, there has been a surge of interest in alternative and natural techniques for preventing and treating gynecological disorders. Numerous studies have focused on exploring treatments that have …

Published: Aug. 6, 2025, midnight
Harnessing the CD16-PI3Kγ axis in peritoneal CD14hi macrophages: A transformative approach to endometriosis management.

Endometriosis (EMS) is a prevalent estrogen-dependent gynecological disorder characterized by ectopic growth of endometrial tissue. Central to its pathophysiology, peritoneal CD14hi macrophages exhibit a pro-EMS phenotype and drive disease progression. …

Published: Aug. 6, 2025, midnight
Management of uterine artery pseudoaneurysm: a case report of noninterventional treatment with systematic review.

Uterine artery pseudoaneurysm (UAP) is a rare but potentially life-threatening condition that can result in severe hemorrhage. Due to its nonspecific clinical presentation, it is often misdiagnosed, leading to delays …

Published: Aug. 5, 2025, midnight
Impaired Decidualization and Angiogenesis in Eutopic Endometrium of Endometriosis: Insights from In Vitro Models.

Endometriosis markedly compromises female fertility, and although endometrial dysfunction likely plays a role in this pathology, its precise mechanistic contributions remain poorly understood. This study aims to investigate the decidualization …

Published: Aug. 1, 2025, midnight
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