This study evaluates the synergistic therapeutic effect of metformin (MET) combined with medroxyprogesterone acetate (MPA) on endometriosis (EM) and investigates the involvement of the steroid receptor coactivator-1 (SRC-1) and mitogen-inducible …
Endometriosis is a common gynecological disease associated with pelvic pain and infertility. Despite several existing theories, the etiology and molecular mechanisms of endometriosis remain to be investigated. Here we report …
The pathogenesis and progression of endometriosis may involve a complex combination of multiple factors, including chronic inflammation and oxidative stress. Hormonal therapy, the current standard for pharmacotherapy in endometriosis, causes …
Endometriosis can impair natural reproduction through multiple mechanisms, including distortion of pelvic anatomy and chronic peritoneal inflammation. On this basis, surgical treatment might be reasonably expected to benefit. However, clinical …
Objective: To analyze multiple aspects of advanced bladder endometriosis surgery, based on the experience of an endometriosis reference center. Methods: This retrospective/prospective study included 80 consecutive patients with deep bladder …
The technique of microneurography has advanced our understanding of the sympathetic nervous system's role in the neurovascular control of blood pressure in humans, yet critical knowledge gaps remain, particularly across …
S. Paul, P. Bhattacharya, P. D. Mahapatra, and S. Swarnakar, "Melatonin Protects Against Endometriosis via Regulation of Matrix Metalloproteinase-3 and an Apoptotic Pathway," Journal of Pineal Research 49, no. 2 …
Oxidative stress has emerged as a key factor regulating female fertility, reproductive aging, and the development of various gynecologic and pregnancy-associated diseases. While physiological concentrations of reactive oxygen species play …
Digital symptom checkers (SCs) are increasingly used to support early symptom recognition and care-seeking, yet evidence on their cost-effectiveness remains limited. We conducted an economic evaluation of a digital SC …