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Endometriosis-related alterations in the endometrium revealed by integrated single-cell and AI-powered approaches.

Endometriosis, affecting 1 in 9 women, presents treatment and diagnostic challenges. To address these issues, we generated a comprehensive single-cell atlas of endometrial tissue, comprising 466,371 cells from 35 endometriosis …

Published: May 20, 2026, midnight
Molecular Characterization of Ovarian Endometriosis in Saudi Arabian Women: Insights into Inflammatory, Autophagic, and Epigenetic Dysregulation.

Ovarian endometriosis (OE) is a chronic, inflammatory gynecological disorder associated with sterility and an elevated risk of ovarian cancer. Despite its high prevalence, the complex molecular mechanisms governing OE pathogenesis …

Published: May 20, 2026, midnight
Preclinical models of female pelvic pain disorders.

Pain is influenced by a complex interplay of biological, psychological, and social factors. Sex has emerged as a key determinant of vulnerability to chronic pain and a major risk factor …

Published: May 20, 2026, midnight
Stromal-only endometriosis catamenial pneumothorax: A diagnostic algorithm with potential pitfalls.

Catamenial pneumothorax (CP) is a rare form of recurrent spontaneous pneumothorax occurring synchronously with menstruation and represents the most common manifestation of thoracic endometriosis. CP predominantly involves the right hemithorax …

Published: May 19, 2026, midnight
Pelvic Müllerian duct cyst with coexisting endometriosis: a case report.

Müllerian duct cyst (MDC) is an uncommon congenital lesion arising from incomplete regression of the paramesonephric duct. It typically presents as a midline pelvic cystic lesion and is often asymptomatic, …

Published: May 19, 2026, midnight
Anti-Müllerian hormone decreased in women with superficial peritoneal endometriosis and associated with an elevated inflammatory profile.

Endometriosis is a common, inflammatory condition impacting 200 million women and those assigned female at birth, where 25-40% experience infertility. Ovarian endometriosis is known to decrease anti-Mullerian hormone (AMH) levels …

Published: May 19, 2026, midnight
Piezo1 mediates hypoxia-induced endometriosis fibrosis via the mtDNA -dependent cGAS-STING pathway.

Endometriosis (EMs) is a prevalent gynecological disorder characterized by the ectopic growth of functional endometrial tissue, and its fibrotic pathology represents a primary contributor to chronic pain and infertility in …

Published: May 19, 2026, midnight
Hypoxia-mediated epigenetic silencing of YTHDF2 promotes endometriosis progression via the NFE2L1-NF-κB axis.

Endometriosis (EMs) is a chronic inflammatory disease characterized by ectopic growth of endometrial-like tissues. N6-methyladenosine (m6A) modification regulates diverse cellular processes, yet its role in EMs remains unclear. Here, we …

Published: May 19, 2026, midnight
Hormonal Dysregulation and Neuroinflammation in Endometriosis: Convergent Druggable Pathways.

Endometriosis is a chronic, estrogen-dependent disorder defined by ectopic endometrial-like tissue growth, persistent inflammation, and aberrant innervation. Emerging evidence indicates that disease progression and symptom severity are driven by a …

Published: May 19, 2026, midnight
An Unusual Diagnosis of Inguinal Pain in a Childbearing-Age Woman: An Inflamed Canal of Nuck Cyst With an Abnormal Leiomyomatous Proliferation.

The canal of Nuck cyst is a rare pathology seen in women in the inguinal canal. It is often mistaken for a hernia or a lipoma; however, diagnosis is confirmed …

Published: May 19, 2026, midnight
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