The Gut-Endometriosis Axis: Genetic Mechanisms and Public Health Implications.
Background/Objectives: Endometriosis is a chronic, estrogen-driven gynecological disorder affecting approximately 10% of reproductive-aged women worldwide, with significant physical, psychosocial, and socioeconomic impacts. Recent research suggests a possible involvement of the …
In Vivo Shadows and In Vitro Light: The Early Embryological Journey Amid Endometriosis.
Endometriosis significantly impacts fertility through complex mechanisms. These include chronic inflammation, oxidative stress, and anatomical distortion. These mechanisms impair oocyte quality, embryo development, and implantation. While in vivo challenges persist, …
IVF/ICSI or surgery as first approach for the treatment of infertility associated with ovarian and deep infiltrating endometriosis? A systematic review and meta-analysis.
This systematic review and meta-analysis (CRD42024588171) compared the effectiveness of surgery followed by IVF/intracytoplasmic sperm injection (IVF/ICSI) with direct IVF/ICSI (i.e. without previous surgery) on the reproductive outcomes of infertile …
Stage-specific autophagy dynamics in reproductive processes and associated disorders.
Autophagy is a highly conserved eukaryotic process that degrades cytoplasmic material within lysosomes, and plays a crucial role in cellular development, function and homeostasis. Recent studies have increasingly revealed the …