Endometriosis is increasingly recognized as a systemic disorder involving complex interactions between nerves and immune cells, driving chronic pain and inflammation beyond the initial theories. Recent breakthroughs highlight aberrant sensory …
Vulvodynia is a chronic vulvar pain condition significantly affecting the quality of life. Its multifactorial etiology is not fully understood, and comprehensive pooled data on associated risk factors are lacking …
Evidence increasingly shows small nerve fibre pathology in subsets of people with fibromyalgia through skin biopsy, corneal confocal microscopy, and microneurography. However, blood-based biomarkers of ongoing neuronal damage, particularly neurofilament …
The LYSET gene encodes the LYSET transmembrane protein, which regulates lysosome biogenesis by activating the mannose-6-phosphate (M6P) pathway. This is an autosomal recessive, ultrarare, and severe progressive skeletal dysplasia with …
Whether endometriosis is a progressive disease remains debated. Central to this debate is understanding the natural history of endometriotic lesions, which are essentially wounds undergoing repeated tissue injury and repair. …
Endometriosis is a chronic gynecological disease characterized by the presence of ectopic endometrium. Achieving effective therapeutic outcomes for endometriosis has always been a significant clinical hurdle because of the high …
Both genetic and environmental factors affect human stature, including overall height and familial short stature (FSS), and it is associated with various health outcomes. However, the study of genetic connections …
Endometriosis, affecting up to 10% of women, is a chronic estrogen dependent disorder where ectopic endometrial-like tissue causes pelvic pain and infertility. Endometriosis is challenging to diagnose due to symptom …