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TGFB1/SMAD3-Driven Macrophage-Myofibroblast Transition Promotes Fibrosis Progression in Endometriosis.

Endometriosis is a chronic gynecological disorder characterized by progressive fibrosis, which is closely associated with clinical symptoms such as dysmenorrhea and infertility. While myofibroblast activation is central to fibrogenesis, the …

Published: Oct. 7, 2025, midnight
Polychlorinated Biphenyls Alter Estrogen Receptor beta-Mediated Epigenetic Regulation, Promoting Endometriosis.

Endometriosis is a pathological condition characterized by the ectopic growth of endometrial cells, leading to chronic pelvic pain and infertility. Epidemiological studies have associated exposure to dioxin-like polychlorinated biphenyls (PCBs), …

Published: Oct. 7, 2025, midnight
Does age influence surgical technique in bowel endometriosis? A multicenter analysis of 1547 cases.

To evaluate whether patient age influences the complexity of the surgical approach for bowel endometriosis, including the technique performed and the route of specimen extraction. Methods: Retrospective, multicenter observational study, …

Published: Oct. 7, 2025, midnight
A Rare Case of Isolated Primary Leiomyoma Discovered Within an Ovarian Endometrioma: A Case Report.

A woman in her 30s presented to the emergency department with a one-day history of acute lower abdominal pain, which was not related to her menstruation and not associated with …

Published: Oct. 5, 2025, midnight
Extracellular granzyme B and K are associated with endometriosis severity in infertile women.

Endometriosis is a chronic inflammatory condition often associated with infertility. The role of granzymes as cytotoxic proteases and immune regulators in endometriosis remains poorly understood. This study evaluated serum and …

Published: Oct. 4, 2025, midnight
Inflammatory Cytokine Signatures Are Associated With Disease Burden and Comorbidity of Episodic Migraine and Endometriosis.

The aim of this study was to characterize inflammatory cytokine profiles in women diagnosed with episodic migraine, endometriosis, or both conditions and to determine how these cytokine patterns relate to …

Published: Oct. 3, 2025, midnight
Psychological, Symptom-Related, and Lifestyle Predictors of Health-Related Quality of Life in Hungarian Women with Endometriosis.

Background: This study was a cross-sectional online survey aimed at examining health-related quality of life and the effect of different symptoms and lifestyle factors on health-related quality of life in …

Published: Oct. 3, 2025, midnight
Effects of Endometriosis, Fibroids, and Other Pathological Conditions on Muscular Contractions in the Human Fallopian Tube.

Ectopic pregnancy (EP) and tubal endometriosis (TEM) directly affect the fallopian tube structure and function, while ovarian cysts (OC) and uterine fibroids (UF) may indirectly influence tubal physiology. These conditions …

Published: Oct. 2, 2025, midnight
Endometriosis-associated infertility: Multi-omics insights into pathogenesis and precision therapeutics.

Endometriosis is a prevalent, estrogen-dependent, inflammatory disease that impairs fertility via hormonal dysregulation, immune dysfunction, oxidative stress/ferroptosis, genetic and epigenetic alterations, and microbiome imbalance. We summarize multi-omics insights and clinical …

Published: Oct. 2, 2025, midnight
Systemic Immune and Tumor Marker Profiles in Ovarian and Deep Infiltrating Endometriosis: Associations with Disease Severity and Symptom Burden.

Endometriosis is a chronic, estrogen-dependent inflammatory disease with heterogeneous clinical manifestations and uncertain systemic immune involvement. This study aimed to characterize peripheral immune profiles and circulating tumor markers in women …

Published: Oct. 1, 2025, midnight
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