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Once Daily Oral Relugolix Combination Therapy Versus Placebo in Patients With Endometriosis-Associated Pain: Two Replicate Phase 3, Randomised, Double-Blind, Studies (SPIRIT 1 and 2).

The author describes the results of a study to examine the effect of three treatment regimens on pain associated with endometriosis.

Published: Oct. 9, 2024, midnight
Progesterone Receptor Status predicts Aggressiveness of Human Endometriotic lesions in Murine Avatars.

To utilize murine avatars for studying human endometriotic lesion response to two different hormonal regimens to determine if PR can prospectively predict response to progestin-based therapy. Endometriosis is a chronic …

Published: Oct. 9, 2024, midnight
P2X3 and P2X2/3 Receptors Inhibition Produces a Consistent Analgesic Efficacy: A Systematic Review and Meta-Analysis of Preclinical Studies.

P2X3 and P2X2/3 receptors are promising therapeutic targets for pain treatment and selective inhibitors are under evaluation in ongoing clinical trials. Here we aim to consolidate and quantitatively evaluate the …

Published: Oct. 9, 2024, midnight
A feasible procedure for laparoscopic cesarean scar defect repair.

In 1995, Morris first described cesarean scar defect (CSD) as an "isthmocele" by macroscopy following hysterectomy in women with a prior cesarean delivery. CSD is associated with gynecological symptoms such …

Published: Oct. 9, 2024, midnight
Concordance between Preoperative #ENZIANi Score and Postoperative #ENZIANs Score Classification-Why Do We Choose #ENZIAN and How Does It Impact the Future Classification Trend?

Objectives: To assess the concordance of the preoperative application of the #ENZIAN classification (#ENZIANi) with the postoperative result (#ENZIANs) using surgical findings as the reference standard. Methods: This retrospective study …

Published: Oct. 9, 2024, midnight
Advances in research on malignant transformation of endometriosis-associated ovarian cancer.

Endometriosis (EMs) is a prevalent chronic gynecological condition that depends on estrogen, marked by the presence of active endometrial tissue (glands and stroma) outside the uterus. Although pathologically benign, it …

Published: Oct. 9, 2024, midnight
The cGAS-STING pathway and female reproductive system diseases.

The cGAS-STING pathway has become a crucial role in the detection of cytosolic DNA and the initiation of immune responses. The cGAS-STING pathway not only mediates protective immune defense against …

Published: Oct. 9, 2024, midnight
In vitro fertilization impact on the risk of breast cancer.

Breast cancer, with its increasing incidence and high mortality rates, remains a major global health challenge, significantly impacting individuals, families, and societies. Understanding the multifactorial risk factors contributing to its …

Published: Oct. 9, 2024, midnight
Descriptive Analysis of Common Fusion Mutations in Papillary Thyroid Carcinoma in Hungary.

Thyroid cancer is the most common type of endocrine malignancy. Papillary thyroid carcinoma (PTC) is its predominant subtype, which is responsible for the vast majority of cases. It is true …

Published: Oct. 8, 2024, midnight
Advances in Mesenchymal Stem Cell Research Applications for Female Infertility-Mechanisms, Efficacy Parameters, Challenges and Future Roadmap.

Infertility affects approximately 15-20% of couples globally, with female factors contributing to nearly half of cases. Conditions such as polycystic ovary syndrome, endometriosis, tubal damage and premature ovarian failure are …

Published: Oct. 8, 2024, midnight
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