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Pharmacokinetic-Pharmacodynamic Modeling and Simulation of Merigolix, a Nonpeptide Gonadotropin-Releasing Hormone Antagonist.

Gonadotropin-releasing hormone (GnRH) antagonists inhibit estrogen synthesis and secretion, making them promising treatment options for estrogen-dependent diseases, such as endometriosis. This study developed a population pharmacokinetic/pharmacodynamic (PK/PD) model for merigolix, …

Published: Dec. 20, 2025, midnight
Copper Intrauterine Device Migration Into Cesarean Scar Niches Without Complications: A Case Report.

Intrauterine devices (IUDs), both hormonal and nonhormonal, are widely used contraceptive methods, with approximately 20% of reproductive-aged women worldwide utilizing them. Although IUDs are generally considered safe and effective, complications …

Published: Dec. 20, 2025, midnight
Non-Invasive Diagnosis of Endometriosis by Questionnaires in Patients Using Contraception.

Background/Objectives: The assessment of endometriosis (EMS)-associated pain is important, but only very few studies address the potential use of questionnaires for non-invasive prediction of the disease. Methods: In a prospective …

Published: Dec. 20, 2025, midnight
How cyclical is Blueprint Medicines Corporation (2L9) stock compared to rivals - July 2025 Gainers & Safe Entry Momentum Stock Tips - Улправда

How cyclical is Blueprint Medicines Corporation (2L9) stock compared to rivals - July 2025 Gainers & Safe Entry Momentum Stock Tips Улправда

Published: Dec. 19, 2025, 10:41 p.m.
How cyclical is Blueprint Medicines Corporation (2L9) stock compared to rivals - July 2025 Gainers & Safe Entry Momentum Stock Tips - ulpravda.ru

How cyclical is Blueprint Medicines Corporation (2L9) stock compared to rivals - July 2025 Gainers & Safe Entry Momentum Stock Tips ulpravda.ru

Published: Dec. 19, 2025, 10:41 p.m.
Quiet Essex life of footballer Michelle Agyemang as she's awarded Young Sports Personality of the Year - Essex Live

Quiet Essex life of footballer Michelle Agyemang as she's awarded Young Sports Personality of the Year Essex Live

Published: Dec. 19, 2025, 12:02 p.m.
Bayer Pakistan strengthens women’s health portfolio by launching new medication to treat endometriosis - Dawn

Bayer Pakistan strengthens women’s health portfolio by launching new medication to treat endometriosis Dawn

Published: Dec. 19, 2025, 8:46 a.m.
Correlation between Polycomb repressive complex proteins and epithelial-mesenchymal transition-associated genes in endometriotic tissues.

Endometriosis is a condition in which functional endometrial glands and stroma are found to grow outside the uterine cavity that can lead to symptoms like dysmenorrhea, dyspareunia, adhesions, and infertility. …

Published: Dec. 19, 2025, midnight
EGR1 promotes ferroptosis in endometriosis through transcriptional activation of HMOX1.

Endometriosis (EM) affects approximately 10% of women of reproductive age and remains a prevalent estrogen-dependent gynecological disorder with limited therapeutic efficacy and high recurrence rates. Ferroptosis-an iron-dependent, non-apoptotic form of …

Published: Dec. 19, 2025, midnight
Archie, Sabrina the Teenage Witch Get Modern Relaunch with Oni Press Deal (Exclusive) - The Hollywood Reporter

Archie, Sabrina the Teenage Witch Get Modern Relaunch with Oni Press Deal (Exclusive) The Hollywood Reporter

Published: Dec. 18, 2025, 9:13 p.m.
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