Endometriosis as a Systemic and Complex Disease: Toward Phenotype-Based Classification and Personalized Therapy.
Endometriosis is traditionally conceptualized as a pelvic lesion-centered disease; however, mounting evidence indicates it is a chronic, systemic, and multifactorial inflammatory disorder. This review examines the molecular dialog between ectopic …
Pro-inflammatory cytokines disrupt in vitro preantral follicle development by targeting granulosa and theca cell functions.
Chronic low-grade inflammation is increasingly recognized as a contributing factor to female infertility. Elevated levels of pro-inflammatory cytokines such as TNF-α, IL-1β, and IL-6 are observed in ovarian conditions including …