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TET3 is a common epigenetic immunomodulator of pathogenic macrophages.

Through a combination of single-cell/single-nucleus RNA-sequencing (sc/snRNA-seq) data analysis, immunohistochemistry, and primary macrophage studies, we have identified pathogenic macrophages characterized by TET3 overexpression (Toe-Macs) in three major human diseases associated …

Published: Aug. 12, 2025, midnight
Women with endometriosis have decreased health-related quality of life until late fertile age: a population-based cohort analysis at ages 31 and 46 years.

What is the health-related quality of life (HRQoL) at fertile and late fertile age in women with history of endometriosis?

Published: Aug. 8, 2025, midnight
Intraoperative transvaginal ultrasound: a novel approach to refine surgical strategy in rectosigmoid endometriosis surgery.

To describe a standardized intraoperative transvaginal ultrasound (IOTVUS) technique for assessing rectosigmoid deep infiltrating endometriosis (DIE), and to explore its potential advantages in guiding real-time surgical decision-making.

Published: Aug. 7, 2025, midnight
Unraveling the Core of Endometriosis: The Impact of Endocrine Disruptors.

Globally, endometriosis affects almost 10% of reproductive-aged women, leading to chronic pain and discomfort. Endocrine-disrupting compounds (EDCs) seem to play a pivotal role as a causal factor. The current manuscript …

Published: Aug. 6, 2025, midnight
Harnessing the CD16-PI3Kγ axis in peritoneal CD14hi macrophages: A transformative approach to endometriosis management.

Endometriosis (EMS) is a prevalent estrogen-dependent gynecological disorder characterized by ectopic growth of endometrial tissue. Central to its pathophysiology, peritoneal CD14hi macrophages exhibit a pro-EMS phenotype and drive disease progression. …

Published: Aug. 6, 2025, midnight
Tiffany Haddish’s silent struggles and surprise baby post: All about her battle with miscarriages and end - Times of India

Tiffany Haddish’s silent struggles and surprise baby post: All about her battle with miscarriages and end Times of India

Published: Aug. 5, 2025, 4:24 a.m.
Tiffany Haddish’s silent struggles and surprise baby post: All about her battle with miscarriages and end - The Times of India

Tiffany Haddish’s silent struggles and surprise baby post: All about her battle with miscarriages and end The Times of India

Published: Aug. 5, 2025, 4:24 a.m.
Design of a peripherally biased NPSR1 antagonist for neuropeptide S induced inflammation.

Neuropeptide S (NPS) is a potent agonist for the GPCR receptor NPSR1, implicated in various physiological and pathological processes, including inflammation. NPSR1 gene polymorphisms have been linked to asthma, inflammatory …

Published: Aug. 5, 2025, midnight
Endometriosis Rates Increasing Across All Ages, Most Common in Women 35–49 - Epic Research

Endometriosis Rates Increasing Across All Ages, Most Common in Women 35–49 Epic Research

Published: July 29, 2025, 9:44 a.m.
Clinical significance of the CXCL6-CXCR1/CXCR2 chemokine signaling pathway in the peritoneal fluid of patients with endometriosis.

Endometriosis is the presence of endometrial tissue outside the uterine cavity with an accompanying chronic inflammatory process. The etiology of the disease is still not fully understood. An important role …

Published: July 29, 2025, midnight
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