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Elevated levels of TRAb IgG autoantibodies are not recognized in endometriosis by the current clinical methods.

Endometriosis can cause gastrointestinal symptoms that sometimes lead to incorrect diagnosis of irritable bowel syndrome (IBS). Receptors of thyroid-stimulating hormone (TSH) are found in the endometrium and are overexpressed in …

Published: Sept. 22, 2025, midnight
Unravelling the Intricate Link: Mast Cells and Estrogen-Induced Pain Sensitization in Endometriosis.

Endometriosis is a prevalent gynaecological disorder characterized by estrogen-dependent lesions. Pain-particularly dysmenorrhea, chronic pelvic pain, and dyspareunia-is the hallmark symptom of endometriosis. While pain mechanisms remain poorly understood, mast cells …

Published: Sept. 21, 2025, midnight
Cumulative live birth rates under three consecutive IVF/ICSI treatment cycles are reduced in women with endometriosis and/or adenomyosis diagnosed by ultrasonography.

Does endometriosis and/or adenomyosis, diagnosed using the International Deep Endometriosis Analysis (IDEA) group and the Morphological Uterus Sonographic Assessment (MUSA) group revised definitions, impact cumulative live birth rates (CLBR) after …

Published: Sept. 20, 2025, midnight
AIF-1 Modulates Endometrial Stromal Cell Proliferation, Invasion, and Migration via Mitochondrial Function.

This study investigates the role of allograft inflammatory factor 1 (AIF-1) in regulating the proliferation, invasion, and migration of endometrial stromal cells (ESCs) in the context of endometriosis, focusing on …

Published: Sept. 19, 2025, midnight
Clinical practice guidelines for the care of people experiencing chronic primary pain: protocol for a systematic review with interpretation against an established chronic pain care priority framework.

Most clinical practice guidelines (CPGs) for assessing and managing people's chronic pain focus on specific pain conditions, body sites or life course stages. This creates complexity for clinicians making care …

Published: Sept. 18, 2025, midnight
Dysregulation of Key Biological Processes in Endometriosis Pathophysiology.

Endometriosis is a typical disorder affecting the female reproductive system and is characterized by the presence of tissue resembling the endometrium both within and beyond the pelvic cavity. Unfortunately, the …

Published: Sept. 18, 2025, midnight
Case Report: Uterine mesothelial cyst in a nulliparous woman-diagnostic and clinical challenges of a rare benign lesion.

Uterine mesothelial cysts (UMCs) are rare, benign lesions that arise from the mesothelial lining of the uterus and are only sporadically documented in the literature. Because of their extremely low …

Published: Sept. 18, 2025, midnight
SPP1 as a key modulator of M2 macrophage polarization promotes endometriosis progression via activation of the FAK/PI3K/AKT pathway: A bioinformatics and experimental study.

Endometriosis (EMs) is a gynecological disorder characterized by chronic inflammation and an aberrant immune microenvironment. In this study, we integrated the GSE6364 dataset from the GEO database to identify differentially …

Published: Sept. 17, 2025, midnight
The strategic role of lipidomics in biomarker identification and diagnosis of gynecological diseases.

Lipidomics, an emerging field in medical research, has deepened our understanding of lipid metabolism, signal transduction pathways, and intercellular communication through qualitative and quantitative analyses of patient lipid profiles. It …

Published: Sept. 17, 2025, midnight
Leveraging the role of the microbiome in endometriosis: novel non-invasive and therapeutic approaches.

Endometriosis (EMS) is an oestrogen-dependent condition characterised by ectopic endometrial-like tissue growth with a chronic and inflammatory nature leading to severe symptoms and reduced quality of life. Emerging evidence implicates …

Published: Sept. 16, 2025, midnight
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