Pharmacokinetic-Pharmacodynamic Modeling and Simulation of Merigolix, a Nonpeptide Gonadotropin-Releasing Hormone Antagonist.
Gonadotropin-releasing hormone (GnRH) antagonists inhibit estrogen synthesis and secretion, making them promising treatment options for estrogen-dependent diseases, such as endometriosis. This study developed a population pharmacokinetic/pharmacodynamic (PK/PD) model for merigolix, …
Personalized Estimation of Fatigue in Endometriosis Using Wrist-Worn Actigraphy Data and Hierarchical Bayesian Modeling.
Endometriosis is a common chronic condition associated with debilitating pain and fatigue. Wearable technology has the potential to improve symptom monitoring in endometriosis where symptom severity has been traditionally evaluated …