Stage-Related Changes in TGF-β Isoforms in PBMC Culture Supernatants in Endometriosis: A Prospective Case-Control Study.
Endometriosis is a chronic inflammatory disease in which transforming growth factor-beta (TGF-β) has been implicated in immune dysregulation, extracellular matrix remodeling, and fibrosis. Data on baseline secretion of TGF-β isoforms …
Comparative analysis of DNA methyltransferase 3 alpha and miR-29b expression in eutopic and ectopic endometrial tissues from endometriosis patients compared to healthy controls: A case-control study.
Epigenetic mechanisms, particularly the roles of DNA methylation and microRNAs, are increasingly recognized in the pathogenesis of endometriosis. DNA methyltransferase 3 (DNMT3) alpha, an important DNA methyltransferase, and miR-29b, a …
Role of soluble EGFR, Fas, and Fas ligand in pelvic pain severity and their association with endometriosis in infertile woman: a case-control study.
Endometriosis, a chronic inflammatory condition linked to pelvic pain and infertility, is characterized by immune dysfunction involving dysregulated apoptosis and cell proliferation. This case-control study included 87 infertile women undergoing …
Increased risk of thromboembolism in adenomyosis: a case-control study.
Does adenomyosis increase the risk of thromboembolic events, including both arterial and venous thromboembolism, compared with endometriosis, and what clinical factors may contribute to this association?
Menstrual Effluent in the Pathogenesis and Diagnosis of Endometriosis-A Systematic Review.
Background: The individual and social burden of endometriosis is high, and the diagnosis is usually delayed by 7-10 years. Menstrual effluent (ME) represents an accessible and uniquely informative biofluid. This …
Systemic Oxidative Stress Markers in Endometriosis: Elevated Advanced Glycation End Products and Sestrin 2 in Women with Ovarian Endometrioma.
Background/Objectives: Endometriosis is a chronic inflammatory disease characterized by ectopic endometrial tissue growth and is strongly associated with oxidative stress; however, systemic biomarkers reflecting this stress response remain limited. Advanced …