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SPP1 as a key modulator of M2 macrophage polarization promotes endometriosis progression via activation of the FAK/PI3K/AKT pathway: A bioinformatics and experimental study.

Endometriosis (EMs) is a gynecological disorder characterized by chronic inflammation and an aberrant immune microenvironment. In this study, we integrated the GSE6364 dataset from the GEO database to identify differentially …

Published: Sept. 17, 2025, midnight
Using systems biology and drug repositioning approaches to discover FDA-approved drugs candidates for endometriosis treatment.

Endometriosis is characterized by the presence of endometrial tissue outside the uterine cavity. The administration of drugs designated for this condition has significant adverse effects, such as signs of estrogen …

Published: Sept. 12, 2025, midnight
Bioinformatics-Based Identification of Differentially Expressed Genes in Endometrial Carcinoma: Implications for Early Diagnosis and Prognostic Stratification - Frontiers

Bioinformatics-Based Identification of Differentially Expressed Genes in Endometrial Carcinoma: Implications for Early Diagnosis and Prognostic Stratification Frontiers

Published: Aug. 29, 2025, 6:56 p.m.
Identification of key genes associated with infertile endometriosis based on bioinformatic analysis.

Endometriosis is a common disease among women of childbearing age. However, the molecular mechanism behind it is still unknown. Therefore, new biomarkers and therapeutic targets are needed to improve the …

Published: July 23, 2025, midnight
Identification of biomarkers for endometriosis based on summary-data-based Mendelian randomization and machine learning.

Endometriosis (EM) significantly impacts the quality of life, and its diagnosis currently relies on surgery, which carries risks and may miss early lesions. Noninvasive biomarkers are urgently needed for early …

Published: April 8, 2025, midnight
Bioinformatics analysis to identify environmental endocrine chemicals that target endometriosis genes.

Endometriosis (EMS) significantly impacts women's health and is influenced by genetic factors and environmental endocrine-disrupting chemicals (EDCs), which interfere with hormonal balance. Using the Gene Expression Omnibus database, we identified …

Published: April 4, 2025, midnight
A new perspective on endometriosis: Integrating eQTL mendelian randomization with transcriptomics and single-cell data analyses.

Endometriosis is caused by the migration of endometrial cells to locations outside the uterine lining. Despite the increasing prevalence of endometriosis, there has been limited research on genetic effects, and …

Published: March 26, 2025, midnight
Identification of FZD7 as a potential ferroptosis-related diagnostic gene in endometriosis by bioinformatics analysis.

An increasing number of research have suggested that ferroptosis plays an important role in endometriosis (EMS). This study was to identify a ferroptosis-related diagnosis gene in EMS by using bioinformatics. …

Published: Feb. 28, 2025, midnight
Figure 4. Differentially expressed genes between migrated and... - ResearchGate

Figure 4. Differentially expressed genes between migrated and... ResearchGate

Published: Feb. 24, 2025, 5:40 p.m.
Overexpression of FOS enhances the malignant potential of eutopic endometrial stromal cells in patients with endometriosis‑associated ovarian cancer.

Endometrial cysts of the ovary (EMC) may develop into endometriosis (EM)‑associated ovarian cancer over time (EAOC), but the pathogenesis of this disease has not been determined. In the present study, …

Published: Feb. 21, 2025, midnight
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