Female reproductive disorders present significant challenges worldwide. Transfer RNA-derived small RNAs (tsRNAs), a structurally diverse class of non-coding RNAs mainly comprising tRNA halves (tiRNAs) and tRNA-derived fragments (tRFs), have emerged …
Endometriosis is a common, estrogen-driven chronic gynecologic disorder defined by the ectopic growth of endometrial-like tissue within the peritoneal cavity. Existing treatment options, primarily surgery and hormonal therapy, are limited …
Endometriosis is a chronic systemic disease affecting ~10% of women, yet its genetic basis and molecular mechanisms remain poorly understood. Hence, here we conducted a genome-wide association study of endometriosis …
BackgroundEndometriosis is a hormone-driven systemic inflammatory condition characterized by endometrial-like lesions which grow throughout the body affecting up to 15% of women worldwide with symptoms including chronic pain, infertility, and …
Endometriosis is a chronic estrogen-dependent disorder that is generally localized in the pelvis affecting up to 10% of women in the reproductive age. Extra-pelvic locations are estimated to 9% of …
Endometriomas are a frequent cause of infertility in reproductive-aged women, often requiring surgery. However, cystectomy for large endometriomas may reduce ovarian reserve, as indicated by decreased anti-Müllerian hormone (AMH) levels. …
Chronic pelvic pain is one of the most prevalent syndromes in family medicine, gynecology, and urology. Chronic pelvic pain patients are often misdiagnosed and have unnecessary prolonged suffering. Both misdiagnosis …
Endometriosis, a chronic inflammatory disease, has been associated with adverse pregnancy and perinatal outcomes, which in turn have been linked to long-term neurological morbidity in the offspring. This study aimed …
Endometriosis (EMs) affects approximately 10% of reproductive-age women worldwide, yet its pathogenesis remains incompletely understood. Abnormal cell differentiation and somatic mutations in the ectopic endometrial microenvironment play critical roles in …
Peritoneal inclusion cysts (PICs) are benign cystic lesions typically observed in women of reproductive age with prior pelvic surgery, endometriosis, or pelvic inflammatory disease. To date, no cases of PICs …