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Using systems biology and drug repositioning approaches to discover FDA-approved drugs candidates for endometriosis treatment.

Endometriosis is characterized by the presence of endometrial tissue outside the uterine cavity. The administration of drugs designated for this condition has significant adverse effects, such as signs of estrogen …

Published: Sept. 12, 2025, midnight
Evaluation of rectal endometriosis treatment with high-intensity focused ultrasound versus surgery: A clinical retrospective multicenter trial.

We conducted a comparative retrospective bicentric study of rectal endometriosis treatment with high-intensity focused ultrasound (HIFU) and surgery in terms of symptoms and treatment-related morbidity at 6 months.

Published: Aug. 21, 2025, midnight
Fertility preservation in endometriosis: evaluating surgical risks and emerging preservation approaches.

Endometriosis poses significant challenges for women of reproductive age, particularly due to its impact on ovarian reserve and fertility. In addition to endometriosis-associated infertility contributing to diminished ovarian reserve by …

Published: Aug. 16, 2025, midnight
AMY109, an interleukin-8 antibody, as a potential target for endometriosis treatment: a commentary.

Published: Aug. 11, 2025, midnight
Anti-cancer Drugs in Endometriosis Management: Mechanisms and Therapeutic Potential.

Endometriosis is a widespread estrogen-driven condition causing pelvic pain and infertility in women. This disease shares five features with cancer: Intrinsic growth signals, insensitivity to antiproliferative signals, impaired apoptosis, induction …

Published: Aug. 7, 2025, midnight
The Impact of Targeted Endometriosis Treatment On Patients with Central Sensitization: Systematic Review and Meta Analysis.

Central sensitization (CSS), a condition where the central nervous system amplifies pain signals, may impact response to treatment of chronic pain conditions. The objective of this study is to determine …

Published: July 26, 2025, midnight
Effects of Deinorgestrel Treatment of Endometriosis on Ovarian Function, Inflammatory Factors, and Pregnancy Rate in Patients.

To compare the effects of deinorgestrel and Guizhi Fuling Capsules on ovarian function, inflammatory variables, and the rate of conception in clients receiving endometriosis treatment.

Published: March 1, 2025, midnight
Mitochondrial dynamics: molecular mechanism and implications in endometriosis.

Endometriosis affects about 10% of women of reproductive age, leading to a disabling gynecologic condition. Chronic pain, inflammation, and oxidative stress have been identified as the molecular pathways involved in …

Published: Jan. 28, 2025, midnight
Central Serous Chorioretinopathy in Endometriosis Treatment with Progestogen: A Metabolic Understanding.

Endometriosis afflicts 10% of women in their reproductive years and nearly half of women with infertility, and its etiology is not yet clear. Pharmacological therapy is generally based on progestins …

Published: Jan. 22, 2025, midnight
Peroxisome Proliferator-Activated Receptor Gamma Coactivator-1-Alpha in Endometriosis: Expression, Regulation, and Potential Role.

The present study was designed to comprehensively analyze the expression profiles of peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α), estrogen-related receptor-α (ERRα), estrogen receptor-β (ERβ), interleukin-6 (IL-6), cysteinyl-aspartic acid-specific protease-3 (caspase-3), and …

Published: Jan. 12, 2025, midnight
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