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Endometriosis as an immune-mediated disease: pathogenetic mechanisms and therapeutic strategies.

Endometriosis, which affects approximately 10% of women of reproductive age, is a complex inflammatory disease with significant immune system disturbances caused by an inadequate immune response to retrograde menstruation and …

Published: Dec. 18, 2025, midnight
Pharmacophoric Investigation of a Natural Product-like Class of Aromatase Inhibitors Using Molecular Modeling.

Endometriosis is a condition affecting approximately 10% of reproductive-age women in which endometrial tissue is found in locations outside the uterus, often causing debilitating symptoms. Aromatase, an enzyme that also …

Published: Dec. 18, 2025, midnight
Towards understanding mare endometrosis: ex vivo study on the role of relaxin.

Mare endometrosis remains a poorly understood pathological process.

Published: Dec. 16, 2025, midnight
[Immunology of fertilization, implantation and pregnancy: Key interactions and therapeutic perspectives].

The immunology of fertilization, implantation and pregnancy is based on a complex balance between maternal immune tolerance and a controlled inflammatory response. Adaptation of the maternal immune system is essential …

Published: Dec. 13, 2025, midnight
Gender-Based Violence Among People With Disabilities: Qualitative Insights on Sexual and Reproductive Health Impacts Across the Life Course.

Women and gender-diverse people with disabilities are at an elevated risk of gender-based violence (GBV). This study examines how women and gender-diverse people with disabilities experience GBV and how such …

Published: Dec. 10, 2025, midnight
Microbiota insights in endometriosis.

Endometriosis affects approximately 10% of women of reproductive age and is characterized by the presence of endometrial-like tissue outside the uterine cavity, leading to chronic pelvic pain, infertility, and a …

Published: Dec. 5, 2025, midnight
Genetic and Epigenetic Components in the Pathogenesis of Adenomyosis and Endometriosis in Adolescents.

Background: Adenomyosis and endometriosis are complex, estrogen-dependent gynecological conditions increasingly diagnosed in adolescents. While traditionally considered diseases of reproductive-age women, emerging evidence suggests a possible developmental origin in some cases, …

Published: Dec. 5, 2025, midnight
Gene Polymorphisms Determining Sex Hormone-Binding Globulin Levels and Endometriosis Risk.

Endometriosis is a hormone-dependent disease, in the pathophysiology of which sex hormones (androgens, estrogens, etc.) are involved. The level of bioactive androgens/estrogens (in the free state) in the organism largely …

Published: Nov. 30, 2025, midnight
Establishment of immortalized ovarian stromal cell lines using Sendai virus vectors: a platform for studying tumor-stroma interactions and carcinogenesis.

We aimed to generate immortalized stromal cell lines from the ovarian and fallopian tube tissues of a single patient using Sendai virus (SeV) vectors and identify candidate stromal genes involved …

Published: Nov. 26, 2025, midnight
Molecular mechanısms of ovarian fibrosis.

Ovarian fibrosis is increasingly recognized as a pivotal factor contributing to ovarian aging, dysfunction and female infertility. It results from chronic or repetitive ovarian injury, such as that caused by …

Published: Nov. 26, 2025, midnight
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