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Repurposing ramipril to mitigate EMT-like transition in endometriosis by PI3K/AKT/S6K1 signalling pathway: a study in endometriosis induced rats.

Endometriosis, an atypical benign disorder, may disrupt epithelial-mesenchymal transition (EMT) due to a dysregulated balance between matrix metalloproteinases (MMPs) and their inhibitors. Ramipril, an angiotensin converting enzyme (ACE) inhibitor, is …

Published: Jan. 28, 2026, midnight
Medicus Gene-Blocking Drug Shows Fast Hormone Control Ahead of Key Endocrine Meet - mychesco.com

Medicus Gene-Blocking Drug Shows Fast Hormone Control Ahead of Key Endocrine Meet mychesco.com

Published: Jan. 20, 2026, 10 p.m.
Establishment and Characterization of a New Immortalized Human Adenomyosis Epithelial-Like Cell Line, tAEC21†.

Adenomyosis occurs when endometrial glands and stroma grow within the uterine myometrium. As a clinically significant disease, adenomyosis causes substantial pelvic pain and heavy menstrual bleeding. It remains understudied due …

Published: Nov. 20, 2025, midnight
Rapamycin improves endometriosis‑related infertility involving ovarian senescence via the PPARα/IGFBP2 pathway.

Endometriosis‑associated infertility is considered to be linked to cellular senescence. The present study assessed whether rapamycin, a senescence inhibitor, ameliorates endometriosis‑associated infertility by upregulating peroxisome proliferator‑activated receptor α (PPARα) and …

Published: Oct. 31, 2025, midnight
ROBO3 Drives Endometriosis Progression via Dual Wnt/β-Catenin Activation and M2 Macrophage Polarization.

Endometriosis, a prevalent gynecological disorder marked by ectopic growth of endometrial-like tissue, demonstrates malignant tumor-like properties including aggressive adhesion and invasiveness. Emerging evidence implicates roundabout guidance receptor 3 (ROBO3) in …

Published: Oct. 15, 2025, midnight
Sirtuin 6 Mediates the Therapeutic Effect of Endometrial Regenerative Cell-derived Exosomes in Alleviation of Acute Transplant Rejection by Weakening c-Myc-dependent Glutaminolysis - Frontiers

Sirtuin 6 Mediates the Therapeutic Effect of Endometrial Regenerative Cell-derived Exosomes in Alleviation of Acute Transplant Rejection by Weakening c-Myc-dependent Glutaminolysis Frontiers

Published: Aug. 27, 2025, 8:36 a.m.
LIN28B Promotes the Progression of Endometrial Cancer through Upregulating MYC and Correlates with Immune Microenvironment - Frontiers

LIN28B Promotes the Progression of Endometrial Cancer through Upregulating MYC and Correlates with Immune Microenvironment Frontiers

Published: June 26, 2025, 1:55 p.m.
The role of IGF2BP3/SPOP/c-Myc loop in paclitaxel resistance of endometrial cancer - Nature

The role of IGF2BP3/SPOP/c-Myc loop in paclitaxel resistance of endometrial cancer Nature

Published: April 17, 2025, 12:18 p.m.
Florence Pugh says she is hard to date: 'I’m tricky' - MyCentralOregon.com

Florence Pugh says she is hard to date: 'I’m tricky' MyCentralOregon.com

Published: April 15, 2025, 10:05 p.m.
A case of delayed diagnosis of disseminated coccidioidomycosis highlights opportunities for improved awareness.

As Coccidioides spp. are endemic in the southwestern United States, awareness of the risk factors for severe disease and dissemination is important to avoid delays in diagnosis and treatment. In …

Published: April 11, 2025, midnight
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