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Endometriosis - on the intersection of modern environmental pollutants and ancient genetic regulatory variants.

Endometriosis is a chronic, estrogen-driven inflammatory disorder affecting approximately 10% of reproductive-aged women globally. Despite increasing genomic insights into advanced-stage disease, the genetic underpinnings of early-stage endometriosis remain poorly understood, …

Published: Nov. 20, 2025, midnight
Perineal Endometriosis Post Vaginal Stenosis Repair.

A 17 year-old 46,XX female patient with a history of urogenital reconstruction was found to have perineal endometriosis at the site of previously repaired vaginal stenosis. The patient presented in …

Published: Nov. 20, 2025, midnight
Peritoneal inclusion cyst causing intestinal obstruction in a 9-year-old girl: A rare pediatric case.

Peritoneal inclusion cyst (PIC) is a rare benign condition with low-risk malignant transformation that typically occurs in adult women with a history of pelvic inflammatory conditions, endometriosis, or prior abdominal …

Published: Nov. 18, 2025, midnight
The role of mitophagy in female reproductive system diseases: from molecular mechanisms to therapeutic strategies.

Mitophagy is a catabolic mechanism that selectively degrades damaged mitochondria and precisely modulates mitochondrial content, thereby maintaining intracellular homeostasis under stress conditions. To date, most reviews on mitophagy have predominantly …

Published: Nov. 18, 2025, midnight
Gene regulation by non-Coding RNAs in infertility: a mechanistic review.

Infertility is a significant global health issue affecting millions of couples, with noncoding RNAs (ncRNAs) emerging as pivotal regulators in reproductive biology. This review explores the roles of various ncRNAs, …

Published: Nov. 17, 2025, midnight
Global trends in the uptake of specialist diagnostic ultrasound and MRI scans for endometriosis: An international cross-sectional survey.

Endometriosis affects 1 in 10 women globally. We aimed to determine health provider involvement and preferred methods of obtaining an endometriosis diagnosis across international jurisdictions. A global cross-sectional survey, distributed …

Published: Nov. 14, 2025, midnight
Long noncoding RNAs and microRNAs in Endometriosis.

Endometriosis represents a prevalent gynaecological disorder, impacting around 10% of the female population and affecting as many as 50% of women who are facing challenges with infertility. The pathogenesis of …

Published: Nov. 13, 2025, midnight
Deciphering the relationship between adenomyosis and the microbiota: a systematic review.

Adenomyosis is a benign displacement of endomerial tissue into the uterine myometrium, the exact pathogenesis of which has not yet been established. Recently, there has been increased research on the …

Published: Nov. 11, 2025, midnight
Association between serum carotenoids and risk of endometriosis evidence from NHANES data.

Endometriosis is a prevalent gynecological disorder, with its pathogenesis potentially linked to oxidative stress. Carotenoids, as natural antioxidants, may play a role in its prevention. This study aimed to investigate …

Published: Nov. 10, 2025, midnight
Exploring endometriosis community needs to co-create the EndoZone digital health platform: a qualitative research study.

Endometriosis is a chronic inflammatory condition that is associated with painful periods and a variety of co-morbid symptoms for 10% of women and people presumed female at birth globally and …

Published: Nov. 10, 2025, midnight
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