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The Microbiome-Gut-Gonad Axis: How Microbial Metabolites Orchestrate Reproductive Physiology, Pathology, and Therapy.

The human microbiome, a dynamic endocrine organ, exerts profound systemic influence through the production of bioactive metabolites. While the microbiome-gut-brain axis is well-established, the direct conduit between the gut microbiota …

Published: July 4, 2026, midnight
Posterior Uterine Rupture during Pregnancy in a Patient with Previous Surgery for Severe Endometriosis: A Case Report.

Deep infiltrating endometriosis (DIE) is a severe pathology requiring complex pelvic surgery, which carries a rare but serious risk of uterine rupture during pregnancy. We report a primiparous patient who …

Published: June 30, 2026, midnight
Chemokine CCL21 promotes the pathological progression of endometriosis by regulating inflammatory cytokine expression and activating the NF-κB signaling pathway.

Endometriosis, affecting approximately 10% of reproductive-aged women worldwide, is widely recognized as a chronic inflammatory disease. Inflammation-related genes (IRGs) play a crucial role in the occurrence and progression of various …

Published: June 29, 2026, midnight
Revisiting endometriosis management: Polyphenols as alternative therapeutic candidates.

Endometriosis (EM) is a common gynecological disorder imposing a considerable burden on the quality of life of women through chronic pain, infertility, and other clinical manifestations. The effectiveness of management …

Published: June 24, 2026, midnight
From Hope to Infection: Tubo-Ovarian Abscess After Frozen Embryo Transfer-A Case Report and Review of the Literature.

Tubo-ovarian abscess is a rare but serious complication of assisted reproductive technologies, typically following oocyte retrieval. We report a case of a 41-year-old woman with endometriosis who developed a tubo-ovarian …

Published: June 22, 2026, midnight
A Rare Coexistence: Uterine Leiomyoma Arising in a Mature Cystic Teratoma and a Pedunculated Endometriotic Cyst Mimicking Leiomyoma-Two Case Reports.

Uterine leiomyomas are common benign tumors, but their clinical presentation can be misleading. We report two unusual cases of pedunculated uterine masses presenting with heavy vaginal bleeding. In the first …

Published: June 21, 2026, midnight
Path beyond the blind end-unravel the imaging spectrum of appendiceal pathologies.

The appendix is involved in a diverse spectrum of inflammatory, infectious, benign, and malignant conditions that extend far beyond acute appendicitis. Although acute appendicitis remains the most common appendiceal emergency, …

Published: June 20, 2026, midnight
Primary umbilical endometriosis masquerading as strangulated umbilical hernia: a diagnostic pitfall.

Primary umbilical endometriosis (Villar's nodule) is a rare entity, representing 0.5%-1% of all endometriosis cases. We report a 37-year-old multiparous woman presenting with a 7-day history of umbilical pain, swelling, …

Published: June 19, 2026, midnight
Case Report: Malignant transformation of deep infiltrating endometriosis: a report of two cases and literature review.

Deep infiltrating endometriosis (DIE) is a severe form of endometriosis that rarely undergoes malignant transformation, and when it does, diagnosis is often difficult. Here, we report two cases of long-standing …

Published: June 18, 2026, midnight
Complex benign gynecology in perimenopause: current evidence and future directions.

Perimenopause is a clinically distinct stage in which abnormal uterine bleeding, fibroids, adenomyosis, endometriosis, and adnexal pathology may require surgical evaluation. Management is complex because symptom burden and structural disease …

Published: June 17, 2026, midnight
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