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GREB1 as a Context-Dependent Molecular Switch in Endometrial Estrogen-Progesterone Crosstalk: From Physiological Receptivity to Endometriosis Pathogenesis-A Narrative Review.

In this narrative review, we summarize current evidence regarding the endometrium undergoes cyclic remodeling driven by estrogen (E2) and progesterone (P4) signaling, with precise coordination essential for receptivity and pregnancy …

Published: Sept. 9, 2026, midnight
Hippo pathway in endometriosis pathogenesis: from cellular dysregulation to therapeutic opportunities.

Endometriosis is a chronic, heterogeneous gynaecological disorder characterised by the presence of endometrial-like tissue outside the uterine cavity and is associated with pain, infertility, and reduced quality of life. Emerging …

Published: Sept. 8, 2026, midnight
Phytochemicals Modulating Receptor Tyrosine Kinase Signaling Networks in Endometriosis.

Endometriosis is a chronic, estrogen-dependent inflammatory condition that is marked by the growth of lesions outside the uterus, along with angiogenesis, fibrosis, immune dysregulation, and pain sensitization. There is now …

Published: Sept. 7, 2026, midnight
Exosomal miR-22-3p targets p53 to regulate endometrial epithelial cell function in the pathogenesis of endometriosis.

Endometriosis (EMs) is a widespread gynecological disease, affecting approximately 6-10% of females of child-bearing age. Despite its significant influence on women's health, the specific pathophysiology remains unclear. The enrichment of …

Published: Sept. 4, 2026, midnight
Modulating the Estrobolome and Inflammatory Microenvironment in Endometriosis: The Role of Microbiome-Targeted Interventions and Nutritional Compounds.

Endometriosis is a chronic estrogen-dependent systemic inflammatory disorder characterized by ectopic implantation of endometrial-like tissue, primarily on the ovaries, pelvic peritoneum, and bowel. According to the World Health Organization (WHO) …

Published: Sept. 3, 2026, midnight
Transcriptome differences in lesions by color, and cancer mutations in endometriosis.

Endometriosis is a disease where cells similar to those of the uterine lining grow outside of the uterus, embedding into tissues and organs in the abdominal cavity, forming lesions and …

Published: Aug. 25, 2026, midnight
Study on the role of miR-433-3p in the occurrence and development of endometriosis.

This study aims to characterize the expression pattern and biological functions of miR-433-3p in endometriosis. Eutopic and ectopic endometrial tissues were collected from endometriosis patients, and the expression level of …

Published: Aug. 21, 2026, midnight
Endothelial cell heterogeneity drives angiogenesis in endometriosis: mechanisms and emerging organoid-based models.

Endometriosis (EMs) is characterized by the establishment and persistence of ectopic lesions, a process fundamentally dependent on aberrant angiogenesis. Endothelial cells (ECs) play a central role in this process; however, …

Published: Aug. 20, 2026, midnight
Identification of potent inhibitors of JUN N-terminal kinases for treatment of endometriosis and associated pain.

Endometriosis, defined as the ectopic growth of endometrial tissue outside of the uterine cavity, is an inflammatory and hormone-dependent disease that causes excruciating pelvic pain, infertility, and significantly decreases quality …

Published: Aug. 19, 2026, midnight
Silencing of SEPT9 inhibits proliferation and migration of endometriotic stromal cells via suppression of the PI3K/AKT signaling pathway.

The aim of this study was to investigate the effects of SEPT9 on proliferation, migration, and apoptosis in endometriotic stromal cells and to explore the underlying mechanisms.

Published: Aug. 17, 2026, midnight
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