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TICAM1-Mediated TLR3/TLR4 Signaling Promotes Endometrial Stromal Cell Proliferation, Migration, and Invasion in Endometriosis via IRF3/IFN-β Axis.

Endometriosis (EMs) is an estrogen-dependent inflammatory disease characterized by the presence of endometrial-like tissue outside the uterine cavity, yet its precise pathogenesis remains incompletely elucidated. TICAM1, a key adaptor protein …

Published: June 4, 2026, midnight
Hypoxia-induced regulations of cell adhesion molecules and their implications for pathogenesis, diagnosis, and treatment of endometriosis.

Endometriosis is a chronic inflammatory disease characterized by the presence of endometrial-like tissue outside the uterine cavity, affecting up to 10% of women of reproductive age. Despite extensive research, its …

Published: June 4, 2026, midnight
UCA1 facilitates endometriosis progression through EIF4A3-mediated stabilization of E2F1 mRNA and enhanced glycolysis.

Long non-coding RNA Urothelial carcinoma-associated 1 (UCA1) is a pivotal regulator in the progression of endometriosis (EMs), yet its mechanistic role remains elusive. This study identified UCA1 as a factor …

Published: June 2, 2026, midnight
68Ga-FAPI PET/CT safely detects multifocal endometriosis: a case report.

Endometriosis can be tough to diagnose accurately, especially when standard imaging misses hidden lesions. We explored whether 68Ga-FAPI-46 PET/CT, a new molecular imaging technique, could spot multifocal endometriosis that conventional …

Published: June 1, 2026, midnight
Placental Extracellular Vesicles Inhibit the Progression of Endometriosis by Inducing Ferroptosis.

Endometriosis (EMs) is an estrogen-dependent chronic inflammatory disease, and its pathogenesis remains unclear. Although the placenta is an organ with tumor-like characteristics, its development, including its invasive function, is tightly …

Published: May 27, 2026, midnight
Garcinol Inhibits the Proliferation of Endometriosis Cells by Regulating Cell Cycle Related Genes and Signaling Pathways.

Endometriosis is a common gynecological disease with high recurrence rates after surgery and the lesions keep unlimited proliferative capacity. The effect of garcinol on cell proliferation has not been investigated …

Published: May 27, 2026, midnight
Identifying Novel Biomarkers and Therapeutic Targets for Endometriosis: Integrative Analysis of the Plasma Proteome and Genome.

There is currently no consensus on the etiology, pathogenesis, or treatment of endometriosis (EM). The discovery of disease-associated plasma proteins with causal genetic evidence provides an opportunity to identify new …

Published: May 24, 2026, midnight
Bioactive factors in Endometriosis Peritoneal Fluid Remodel Human Cardiomyocytes.

Endometriosis is associated with increased cardiovascular disease (CVD) risk, yet the cellular basis for this relationship remains unclear. We examined whether peritoneal fluid (PF) from women with endometriosis alters cardiomyocyte …

Published: May 22, 2026, midnight
ASPM promotes the progression of ovarian endometriosis by modulating the cell cycle and activating the Wnt/β-catenin signaling pathway.

Endometriosis (EMs) is a common gynecological disorder associated with impaired fertility and reduced quality of life. This study investigated abnormal spindle-like microcephaly-associated protein (ASPM), identified as a hub gene in …

Published: May 20, 2026, midnight
Molecular Characterization of Ovarian Endometriosis in Saudi Arabian Women: Insights into Inflammatory, Autophagic, and Epigenetic Dysregulation.

Ovarian endometriosis (OE) is a chronic, inflammatory gynecological disorder associated with sterility and an elevated risk of ovarian cancer. Despite its high prevalence, the complex molecular mechanisms governing OE pathogenesis …

Published: May 20, 2026, midnight
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