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Pharmacokinetic-Pharmacodynamic Modeling and Simulation of Merigolix, a Nonpeptide Gonadotropin-Releasing Hormone Antagonist.

Gonadotropin-releasing hormone (GnRH) antagonists inhibit estrogen synthesis and secretion, making them promising treatment options for estrogen-dependent diseases, such as endometriosis. This study developed a population pharmacokinetic/pharmacodynamic (PK/PD) model for merigolix, …

Published: Dec. 20, 2025, midnight
Copper Intrauterine Device Migration Into Cesarean Scar Niches Without Complications: A Case Report.

Intrauterine devices (IUDs), both hormonal and nonhormonal, are widely used contraceptive methods, with approximately 20% of reproductive-aged women worldwide utilizing them. Although IUDs are generally considered safe and effective, complications …

Published: Dec. 20, 2025, midnight
Non-Invasive Diagnosis of Endometriosis by Questionnaires in Patients Using Contraception.

Background/Objectives: The assessment of endometriosis (EMS)-associated pain is important, but only very few studies address the potential use of questionnaires for non-invasive prediction of the disease. Methods: In a prospective …

Published: Dec. 20, 2025, midnight
Perceptions of endometriosis surgery on TikTok: quality and implications for patient counselling.

TikTok is a popular platform for sharing health experiences, including those related to endometriosis. However, the quality and tone of the surgical information shared remain unclear.

Published: Dec. 19, 2025, midnight
Correlation between Polycomb repressive complex proteins and epithelial-mesenchymal transition-associated genes in endometriotic tissues.

Endometriosis is a condition in which functional endometrial glands and stroma are found to grow outside the uterine cavity that can lead to symptoms like dysmenorrhea, dyspareunia, adhesions, and infertility. …

Published: Dec. 19, 2025, midnight
Vascular Involvement in Endometriosis and Adenomyosis (Reply to Letter-to-the-Editor).

Published: Dec. 19, 2025, midnight
EGR1 promotes ferroptosis in endometriosis through transcriptional activation of HMOX1.

Endometriosis (EM) affects approximately 10% of women of reproductive age and remains a prevalent estrogen-dependent gynecological disorder with limited therapeutic efficacy and high recurrence rates. Ferroptosis-an iron-dependent, non-apoptotic form of …

Published: Dec. 19, 2025, midnight
Molecular Regulation of FOXO1 and Its Pathophysiological Significance in Endometriosis: A Narrative Review.

Endometriosis is a chronic inflammatory disorder that affects approximately 10% of women of reproductive age and exhibits tumor-like characteristics such as invasion, recurrence, and hormone-dependent proliferation despite its benign nature. …

Published: Dec. 19, 2025, midnight
Usage of methods polarization-phase mueller-matrix introscopy for early diagnosis of endometriosis based on study of dehydrated films of peritoneal fluid.

Aim: To assess the effectiveness of early diagnosis of endometriosis using polarization-phase Muller-matrix introscopy methods of scattering dehydrated films of peritoneal fluid.

Published: Dec. 18, 2025, midnight
Characteristics and health factors influencing menstrual changes after COVID-19 vaccination: A Spanish retrospective observational study in currently menstruating women.

There is increasing evidence that menstrual changes (MC) should be considered as an adverse event resulting from COVID-19 vaccination. However, the contributing health factors are still poorly understood.

Published: Dec. 18, 2025, midnight
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