Exploring the mechanisms of luteolin in treating polycystic ovary syndrome and endometriosis via network pharmacology, molecular docking, and molecular dynamics simulation.
This study aims to elucidate the molecular mechanisms underlying luteolin's therapeutic effects on polycystic ovary syndrome (PCOS) and endometriosis (EM), thereby providing a theoretical foundation for developing novel treatment strategies. …
Curcumin modulates the function of SPP1+ macrophages via NF-κB signaling to alleviate endometriosis.
Endometriosis is a complex gynecological disorder with prominent cellular heterogeneity, and its key pathogenic cell subsets and core molecular mechanisms remain elusive, which restricts the development of effective therapeutic strategies. …
Inflammasomes meet organoids and artificial intelligence: unraveling the complexity of gynecological inflammation.
Gynecological diseases represent a persistent global health burden. According to a WHO report, the global incidence of gynecological diseases exceeds 65%. Furthermore, over 90% of women suffer from gynecological issues …
LRP1 as a potential diagnostic and immunomodulatory target in endometriosis: evidence from multi-omics and single-cell analyses.
Endometriosis (EMS) is a common gynecological disease that seriously affects women's health and quality of life. However, the detailed dynamic cellular and molecular mechanisms underlying EMS pathogenesis remain largely unknown. …