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Is the EMpressin Injection in ENDOmetrioma eXcision Surgery Useful? The EMENDOX Study.

Background: Endometrioma recurrence after laparoscopic cystectomy remains a clinical challenge in the long-term management of endometriosis. The Empressin Injection Technique (EIT), which involves the use of a vasopressin analog during …

Published: Oct. 30, 2025, midnight
Defects in the DNA Damage Response of Patient-derived Endometriosis Stromal Cells.

With each menstrual cycle, endometrial cells rapidly proliferate and decidualize in preparation for pregnancy. Such rapid proliferation generates replication stress and results in DNA damage with irreparable cells undergoing senescence. …

Published: Oct. 30, 2025, midnight
Reframing Endometriosis: Interplay of NETs, Macrophages, and Lymphocytes at the Crossroads of Disease Progression, Infertility, and Malignant Transformation.

Endometriosis (ENDO) is a painful, chronic gynecological disease widely affecting women globally. While traditionally classified as a hormonal disorder, ENDO is now increasingly recognized as a multifaceted immune-mediated syndrome driven …

Published: Oct. 29, 2025, midnight
Multimodal large language models for women's reproductive mental health.

Women's risk of mental health conditions fluctuates across the lifespan with hormone-mediated reproductive transitions. Reproductive psychiatry, a relatively new subspecialty, focuses on preventing and treating these conditions throughout various reproductive …

Published: Oct. 28, 2025, midnight
Global, regional, and national burden and trends of endometriosis, 1990-2021: an analysis of the global burden of disease study 2021 and forecast to 2050.

Endometriosis is highly prevalent but remains under-researched. This study, using the latest data, aims to provide a comprehensive assessment of the burden of endometriosis on a global scale.

Published: Oct. 28, 2025, midnight
Risk factors for postoperative recurrence of deep infiltrating endometriosis during a 6- to 12-year follow-up.

This study aimed to identify risk and protective factors for postoperative recurrence of deep infiltrating endometriosis (DIE). We analyzed 320 patients undergoing laparoscopic excision with ≥ 6 years follow-up at …

Published: Oct. 28, 2025, midnight
Stage-Specific outcomes of robotic transvaginal NOTES hysterectomy in endometriosis: A comparative study.

The objective was to assess outcomes of robotic-assisted transvaginal natural orifice transluminal endoscopic surgery (RA-vNOTES) performed for hysterectomy and endometriosis excision. We conducted a retrospective case series across two hospitals …

Published: Oct. 27, 2025, midnight
The Nexus of Iron, Senescence, and Fibrosis in Endometriosis: A Narrative Review.

Endometriosis is a prevalent chronic inflammatory condition impacting 5-10% of reproductive-age women, commonly resulting in debilitating pelvic pain and infertility. Despite extensive research efforts, the precise underlying pathophysiology remains largely …

Published: Oct. 27, 2025, midnight
Molecular mechanisms and Biological Functions of Autophagy in Endometrial Diseases.

Autophagy is a highly conserved cellular process crucial for maintaining cellular homeostasis by degrading damaged organelles and misfolded proteins. Emerging evidence highlights its pivotal role in endometrial diseases, including endometriosis, …

Published: Oct. 27, 2025, midnight
Acupoint application improves IVF outcomes and rescues granulosa cell steroid metabolic dysregulation in ovarian endometriosis.

Ovarian endometriosis (OE), characterized by endometriotic cysts, adversely affects ovarian function and comprises in vitro fertilization and embryo transfer (IVF-ET) outcomes. Acupoint application therapy (AAT), which integrates transdermal drug delivery …

Published: Oct. 27, 2025, midnight
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