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Biotechnological progresses in modelling the human endometrium: the evolution of current in vitro techniques and emerging trends.

The endometrium plays a fundamental role in the reproductive system yet many etiologies of infertility-related endometrial diseases such as endometriosis, adenomyosis, Asherman's syndrome or endometrial cancer remain unknown. There are …

Published: Dec. 3, 2024, midnight
Creatine promotes endometriosis progression by inducing M2 polarization of peritoneal macrophages.

Endometriosis is a chronic inflammatory disease characterized by the growth of endometrium-like tissues outside the uterine cavity, with an unclear pathogenesis. Analysis of single-cell sequencing data revealed the pivotal role …

Published: Dec. 1, 2024, midnight
Beyond the pelvis: A case of umbilical endometriosis.

Umbilical endometriosis is defined as an ectopic localization of functional endometrium at the level of the umbilicus. It is a rare condition, representing 0.5% to 1% of all extragenital endometriosis …

Published: Nov. 30, 2024, midnight
Extracellular vesicle-packaged PKM2 from endometriotic stromal cells promotes endometrial collagen I deposition by inhibiting autophagy in endometriosis.

Aberrant endometrial collagen I deposition during the implantation window impairs endometrial stromal cell (ESC) decidualization, which may contribute to lower pregnancy rate in endometriosis (EMs) patients with in vitro fertilization …

Published: Nov. 23, 2024, midnight
Decreased expression of Syndecan- 1 (CD138) in the endometrium of adenomyosis patients suggests a potential pathogenetic role.

Adenomyosis is a special subtype of endometriosis, affecting the myometrium, affecting about 20% of women in the reproductive age period. Clinical symptoms and intensity are diverse and can vary from …

Published: Nov. 20, 2024, midnight
Endometriosis: cannabidiol therapy for symptom relief.

Endometriosis is a common, chronic, incurable condition the hallmark of which is the presence of lesions (tissue resembling endometrium) in sites outside the womb, with symptoms including chronic debilitating pain …

Published: Nov. 14, 2024, midnight
Autophagy Involvement in Non-Neoplastic and Neoplastic Endometrial Pathology: The State of the Art with a Focus on Carcinoma.

Autophagy is a cellular process crucial for maintaining homeostasis by degrading damaged proteins and organelles. It is stimulated in response to stress, recycling nutrients and generating energy for cell survival. …

Published: Nov. 12, 2024, midnight
The Critical Role of Host and Bacterial Extracellular Vesicles in Endometriosis.

Endometriosis is a chronic, inflammatory, oestrogen-dependent disorder that is defined by the presence of endometrium-like tissue in the extra-uterine environment. It is estimated to affect approximately 10% of women of …

Published: Nov. 12, 2024, midnight
Diagnostics and Surgical Treatment of Deep Endometriosis-Real-World Data from a Large Endometriosis Center.

Background: Deep endometriosis (DE) is a special form of endometriosis, one of the most common benign diseases in gynecology. In the specific case of DE, ectopic endometrium can be found …

Published: Nov. 11, 2024, midnight
Symptomatic Uterine Rudiments in Adolescents and Adults with Mayer-Rokitansky-Küster-Hauser Syndrome (MRKHS): Management and Outcomes.

Background: Women with an aplastic uterus (ESHRE/ESGE classification) or Müllerian agenesis (ASRM MAC 2021) might present with functional uterine remnants. Our study aimed to report the clinical course of symptomatic …

Published: Nov. 10, 2024, midnight
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