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Endometriosis in Carriers of a Pathogenic Variant in BRCA1 or BRCA2: A Descriptive Analysis of a Large Multicentral BRCA Carrier Cohort.

Background: Endometriosis affects an estimated 10% of reproductive-aged women and is associated with increased ovarian cancer risk. While BRCA1/2 mutations are established risk factors for ovarian cancer, their association with …

Published: Dec. 1, 2025, midnight
m6A-Related SNPs in endometriosis and ovarian cancer: implications for chemoresistance and therapeutic targeting.

Ovarian cancer (OC) is highly lethal, largely due to late diagnosis and chemoresistance. Endometriosis (EM) increases the risk of specific OC subtypes, but the molecular connection between the two diseases …

Published: Nov. 27, 2025, midnight
Women's perceptions of sexological interview during gynaecological consultations: A cross-sectional study.

Sexological interviews in gynecological consultations remain a practice that is not routinely undertaken despite the importance of sexual health. The objectives of this study were to investigate patients' expectations from …

Published: Nov. 26, 2025, midnight
Establishment of immortalized ovarian stromal cell lines using Sendai virus vectors: a platform for studying tumor-stroma interactions and carcinogenesis.

We aimed to generate immortalized stromal cell lines from the ovarian and fallopian tube tissues of a single patient using Sendai virus (SeV) vectors and identify candidate stromal genes involved …

Published: Nov. 26, 2025, midnight
Molecular mechanısms of ovarian fibrosis.

Ovarian fibrosis is increasingly recognized as a pivotal factor contributing to ovarian aging, dysfunction and female infertility. It results from chronic or repetitive ovarian injury, such as that caused by …

Published: Nov. 26, 2025, midnight
Network pharmacology prediction of UA in targeting endometriosis progression to endometrial cancer.

Endometriosis is a gynecological disorder predominantly affecting women of reproductive age and is considered a potential risk factor for the development of endometrial cancer. However, the molecular mechanisms underlying the …

Published: Nov. 26, 2025, midnight
The immunotherapy era in ovarian clear cell carcinoma: current evidence and future perspective.

Ovarian clear cell carcinoma (OCCC) is a rare, aggressive epithelial ovarian cancer subtype, accounting for approximately 10% of cases and associated with a poor prognosis due to chemoresistance and unique …

Published: Nov. 26, 2025, midnight
Mesonephric-like Adenocarcinoma (MLA) Diagnostic Criteria and Controversies: Perspectives and Guidance From Pathologists in the MLA Consortium.

Mesonephric-like adenocarcinoma (MLA) is a rare and aggressive gynecologic malignancy that has only been recognized in the last decade. It arises in the endometrium, ovaries, and other extrauterine sites (often …

Published: Nov. 24, 2025, midnight
Massive serous cystadenofibroma with incidental umbilical endometriosis in a morbidly obese patient presenting as acute respiratory compromise.

We present a case of a woman in her 50s with a rapidly expanding giant serous cystadenofibroma of the ovary. The 40-kg mass displaced her bowel and splinted her diaphragm, …

Published: Nov. 24, 2025, midnight
MiRNome alterations drive the malignant transformation of endometriosis into endometriosis-correlated ovarian cancer.

Endometriosis (EMS) is a chronic gynecological condition affecting 6-10% of reproductive-age women. These lesions, albeit of benign nature, present cancer-like features, and may progress to epithelial ovarian cancer (EOC) through …

Published: Nov. 21, 2025, midnight
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