Synergistic RU486 and olaparib therapy enhances apoptosis in endometriosis by simultaneously targeting hormonal signalling and DNA repair.
Endometriosis is a chronic, hormone-dependent disorder characterized by ectopic implantation of endometrial tissue, often accompanied by pain and infertility. Although the progesterone receptor modulator RU486 is effective for pain relief, …
Correction: Met Is the Most Frequently Amplified Gene in Endometriosis-Associated Ovarian Clear Cell Adenocarcinoma and Correlates with Worsened Prognosis.
[This corrects the article DOI: 10.1371/journal.pone.0057724.].
The letrozole use in reproductive medicine: Beyond aromatase inhibition - a comprehensive review.
Letrozole and other aromatase inhibitors are increasingly recognized as first-line ovulation induction (OI) medications, offering an efficient and physiologic approach to ovarian stimulation that enhances outcomes in reproductive medicine. By …
Central sensitization in women with endometriosis: a cross-sectional study.
Pain is the primary symptom of endometriosis and may progress into a chronic, acyclic condition driven by neuroinflammatory mechanisms, leading to neuropathic and ultimately nociplastic pain. Central sensitization, a form …
Abuse history as a modifier of symptom phenotype in endometriosis: Insights from a multidimensional retrospective cohort.
Endometriosis is a heterogeneous pain condition with variable symptom expression. Abuse history has been associated with amplified pain, gastrointestinal symptoms, and central sensitization in varying populations; however, whether these effects …
VIDEO ARTICLE Retrorectal Endometriotic Lesion Involving Sacral Roots ........Surgical Technique for Nerve-Sparing Excision and Pain Relief.
To present a laparoscopic nerve-sparing technique for the excision of a retrorectal fibrotic lesion involving the sacral roots (S2-S4), with additional dissection of the lumbosacral trunk based on the patient's …