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Follicular fluid-derived exosomal LINC02701 promotes granulosa cell apoptosis through the GRP75-P53 axis in active endometriosis.

Endometriosis (EMs)-associated infertility has been linked to alterations in the follicular microenvironment; however, the role of exosomal long non-coding RNAs (lncRNAs) in granulosa cell dysfunction remains incompletely understood.

Published: May 22, 2026, midnight
Bioinformatics and machine learning-driven discovery of candidate tissue diagnostic markers for endometriosis with experimental verification.

Endometriosis is a complex gynecological disorder lacking reliable biomarkers. This study aimed to identify core diagnostic genes through integrated computational approaches. Multiple endometriosis transcriptomic datasets were analyzed.

Published: May 22, 2026, midnight
Extracellular Vesicles in Endometriosis: A Comprehensive Review of Biological Insights and Methodological Challenges.

Endometriosis is a complex disorder associated with dysregulated immune, hormonal, and microenvironmental signaling. Extracellular vesicles (EVs) are important mediators of intercellular communication and may contribute to disease pathogenesis, biomarker discovery, …

Published: May 22, 2026, midnight
One in two Spanish women with endometriosis takes more than four years to be diagnosed, according to a report - Demócrata

One in two Spanish women with endometriosis takes more than four years to be diagnosed, according to a report Demócrata

Published: May 21, 2026, 3:45 p.m.
ADVANTAGE: Advanced discovery of visceral analgesics by neuroimmune targets and the genetics of extreme human phenotype, a study protocol.

Chronic visceral pain affects over 20% of adults globally but remains poorly understood, significantly impacting quality of life and healthcare costs. Limited understanding and diagnostic misconceptions hinder effective management, particularly …

Published: May 21, 2026, midnight
Yearning for movement. A qualitative interview study exploring physical activity in the context of endometriosis-associated chronic pain.

BackgroundChronic pain is a common symptom of endometriosis with significant negative impact on physical and social activities. Patients perceive that healthcare professionals lack knowledge about the condition, and that available …

Published: May 21, 2026, midnight
Developmental Versus Chromosomal Competence in Endometriosis: A Stepwise IVF Outcome Analysis.

Background and Objectives: Endometriosis is a multifactorial gynecological condition associated with impaired fertility; however, its impact on embryo competence remains incompletely understood. This study aimed to evaluate embryo competence through …

Published: May 21, 2026, midnight
Is Recurrent Endometriosis a Reprogrammed Disease? Molecular Persistence Beyond Surgical Clearance.

Background: Endometriosis is traditionally conceptualized as a localized gynecological disorder characterized by the presence of ectopic endometrial tissue. However, high recurrence rates following apparently complete surgical excision challenge this lesion-based …

Published: May 21, 2026, midnight
Multi-omics Mendelian randomization integrating metabolism, microbiome and immunity supports a putative gut-immune-pelvic pathway in deep infiltrating endometriosis.

Deep infiltrating endometriosis (DIE) is a highly fibrotic and deeply invasive subtype of endometriosis that causes severe pelvic pain, infertility and marked impairment of quality of life. Metabolic, microbial and …

Published: May 21, 2026, midnight
Primary Cutaneous Endometriosis of the Umbilicus: A Diagnostic Challenge.

Umbilical endometriosis, or Villar's nodule, is a rare form of cutaneous endometriosis in which ectopic endometrial tissue involves the umbilical skin. It may occur without any history of abdominal or …

Published: May 21, 2026, midnight
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